Towards peptide-substituted titanocene anticancer drugs

• Published in: Polyhedron Vol. 30; no. 14; pp. 2387 - 2390
• Main Authors: Zagermann, Johannes, Deally, Anthony, Metzler-Nolte, Nils, Müller-Bunz, Helge, Wallis, Denise, Tacke, Matthias
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 30.08.2011; Elsevier
• Subjects: [3+2] Cycloaddition; Bioorganometallic chemistry; Chemistry; Chemistry, Inorganic & Nuclear; Crystallography; Enkephalin; Metal-based anticancer drugs; Physical Sciences; Science & Technology; Targeting vector; Titanocene dichloride; Bioorganometallic chemistry; Titanocene dichloride; [3+2] Cycloaddition; Metal-based anticancer drugs; Targeting vector; Enkephalin; MICE; ANTITUMOR-ACTIVITY; TUMORS; UNITS

An alkyne-substituted titanocene dichloride derivative was synthesised through the hydridolithiation reaction of an appropriately substituted fulvene. This titanocene dichloride derivative was then coupled with an azide-functionalised methylester-protected phenylalanine in a “click reaction” using a...