Quadrupole-Linear Ion Trap Tandem Mass Spectrometry System for Clinical Biomarker Analysis

• Published in: Engineering (Beijing, China) Vol. 16; no. 9; pp. 56 - 64
• Main Authors: Fang, Xiang, Xie, Jie, Chu, Shiying, Jiang, You, An, Yuting, Li, Chang, Gong, Xiaoyun, Zhai, Rui, Huang, Zejian, Qiu, Chunling, Dai, Xinhua
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2022; College of Instrument Science and Electrical Engineering,Jilin University,Changchun 130026,China%College of Instrument Science and Electrical Engineering,Jilin University,Changchun 130026,China; Technology Innovation Center of Mass Spectrometry for State Market Regulation,Center for Advanced Measurement Science,National Institute of Metrology,Beijing 100029,China%Technology Innovation Center of Mass Spectrometry for State Market Regulation,Center for Advanced Measurement Science,National Institute of Metrology,Beijing 100029,China
• Subjects: Biomarker; Collision-induced dissociation; Linear ion trap; Quadrupole; Space charge effect; Quadrupole; Biomarker; Space charge effect; Linear ion trap; Collision-induced dissociation

The accurate and efficient measurement of small molecule disease markers for clinical diagnosis is of great importance. In this study, a quadrupole-linear ion trap (Q-LIT) tandem mass spectrometer was designed and built in our laboratory. Target precursor ions were first selected in the quadrupole,...