The Relationship Between Anemia and Parathyroid Hormone Levels in Patients With Kidney Failure Undergoing Hemodialysis Treatment in Georgia

• Published in: Curēus (Palo Alto, CA) Vol. 16; no. 7; p. e64021
• Main Authors: Shavgulidze, Elene, Papiashvili, Nikoloz, Jatchvadze, Goga, Chikobava, Elisabed, Mennambath, Krithika, Baig, Adil, Hariharan, Nithesh, Tchokhonelidze, Irma
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 07.07.2024; Cureus
• Subjects: Age; Anemia; Chi-square test; Correlation analysis; Endocrinology/Diabetes/Metabolism; Hemodialysis; Hemoglobin; Internal Medicine; Kidney diseases; Medical records; Metabolism; Nephrology; Patients; Phosphorus; Variance analysis; Vitamin D; United States > US; Georgia; hemodialysis; kidney failure; parathyroid hormone; hyperparathyroidism; anemia
• DOI: 10.7759/cureus.64021
• ISSN: 2168-8184

Chronic kidney disease (CKD) and its associated complications, such as anemia and secondary hyperparathyroidism (SHPT), pose significant challenges to global healthcare systems. This study explores the demographic and clinical characteristics of 284 kidney failure (KF) patients undergoing hemodialysis, in an effort to shed light on the possible association between anemia and SHPT. A proven connection between the two could theoretically influence the management plans for CKD patients, with the hopes of achieving lower morbidity and/or mortality in this patient group. A retrospective, cross-sectional, real-world data analytical study was conducted at a hemodialysis center in Tbilisi, Georgia, encompassing a sample size of n = 284 patients on maintenance hemodialysis. The data analyzed was extracted from patients' medical records. According to our results, the prevalence of anemia was strikingly high at 82.04%, underlining its substantial burden within this patient population. Our analysis revealed a notable systemic association between anemia and SHPT, particularly when considering hemodialysis vintage. However, our final analysis model revealed no statistically significant association between anemia and intact parathyroid hormone (iPTH) levels.  Conclusion: Our study revealed a significant systemic relationship between anemia and SHPT when hemodialysis duration was considered, despite initial analyses showing no direct association. Future research should focus on longitudinal and multi-center studies to better understand this relationship, aiming to enhance the care and management of CKD patients on hemodialysis.