Synthesis and biological evaluation of ternary silver compounds bearing N,N-chelating ligands and thiourea: X-ray structure of [{Ag(bpy)(μ-tu)}2](NO3)2 (bpy=2,2′-bipyridine; tu=thiourea)

• Published in: Polyhedron Vol. 79; pp. 197 - 206
• Main Authors: Segura, Daniel F., Netto, Adelino V.G., Frem, Regina C.G., Mauro, Antonio E., da Silva, Patrícia B., Fernandes, José A., Paz, Filipe A.A., Dias, Amanda L.T., Silva, Naiara C., de Almeida, Eduardo T., Marques, Marcos J., de Almeida, Letícia, Alves, Karina F., Pavan, Fernando R., de Souza, Paula C., de Barros, Heloisa B., Leite, Clarice Q.F.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 05.09.2014
• Subjects: 1,10-Phenanthroline; Antifungal and antibacterial activity; Antileishmanial activity; Silver(I); Tuberculosis; Silver(I); 1,10-Phenanthroline; Tuberculosis; Antileishmanial activity; Antifungal and antibacterial activity

Three new ternary silver(I) compounds were synthesised, characterized and had their antimycobacterial, antileishmanial, antifungal and antibacterial activities evaluated. Compound [{Ag(phen)(μ-tu)}2](CF3SO3)2 (2) was very effective against intracellular amastigote of L. amazonensis (IC50=4.77±0.33μM...