Gene expression studies in primary human acute and chronic wound fibroblasts treated with most popular wound healing phytoextracts

• Published in: South African journal of botany Vol. 155; pp. 205 - 213
• Main Authors: Monika, Prakash, Chandraprabha, MN, Murthy, KN Chidambara
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.04.2023
• Subjects: Chronic wounds; Fibroblasts; Gene expression; Phytoextracts; Wound healing; Wound healing; FGF; DMSO; VEGF; Gene expression; bFGF; Chronic wounds; DMEM; α-SMA; MMP-2; TNF-α; FBS; Fibroblasts; TGF-β; AWFs; GAPDH; RT-qPCR; CWFs; Phytoextracts

•Phytoextracts namely, catechin, epicatechin, curcumin, garlic, pomegranate peel and neem had significant influence on AWFs and CWFs treated cells by up regulating wound healing promoting genes or down regulating wound healing resistance genes.•Epicatechin rich extract was found to be the best as it...