Grafting-from lipase: utilization of a common amino acid residue as a new grafting site

• Published in: Polymer chemistry Vol. 9; no. 37; pp. 4651 - 4659
• Main Authors: Kovaliov, Marina, Cheng, Cooper, Cheng, Boyle, Averick, Saadyah
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 07.10.2018
• Subjects: Acrylamide; Addition polymerization; Amino acids; Aspartic acid; Catalysis; Chain transfer; Chemical synthesis; Enzyme activity; Grafting; High temperature; Initiators; Lipase; Lysine; Polymer chemistry; Polymers; Proteins; Residues

Protein–polymer hybrids are used in a variety of fields including catalysis, detection, and therapeutics. The grafting-from method for the synthesis of these biohybrids has gained popularity due to the ease of synthesis and purification. In this method, an initiator or chain transfer agent (CTA) is...