A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients

• Published in: Clinical pharmacokinetics
• Main Authors: Francke, Marith I., Sassen, Sebastiaan D. T., Lloberas, Nuria, Colom, Helena, Elens, Laure, Moudio, Serge, de Vries, Aiko P. J., Moes, Dirk Jan A. R., van Schaik, Ron H. N., Hesselink, Dennis A., de Winter, Brenda C. M.
• Format: Journal Article
• Language: English
• Published: Switzerland 30.06.2025

Tacrolimus treatment is complicated by its narrow therapeutic range and large inter- and intra-patient variability. This study aimed to develop a population pharmacokinetic model and dosing algorithm to predict an individual's dose requirement following living and deceased donor kidney transpla...