Seroprevalence to Schistosoma Soluble Egg Antigen among Nomadic Pastoralists Residing in Northern Senegal

• Published in: The Journal of parasitology Vol. 109; no. 6; pp. 580 - 587
• Main Authors: Seck, Mame Cheikh, Badiane, Aida Sadikh, Thwing, Julie, Ndiaye, Mouhamadou, Diongue, Khadim, Ndiaye, Ibrahima Mbaye, Diallo, Mamadou Alpha, Sy, Mohamed, Gomis, Jules François, Ndiaye, Tolla, Gaye, Aminata, Lee, Yeuk-Mui, Secor, W. Evan, Ndiaye, Daouda, Rogier, Eric
• Format: Journal Article
• Language: English
• Published: United States Allen Press Inc 01.11.2023
• Subjects: Adults; Age; Antibodies; Antibody response; Antigens; Confidence intervals; Data points; Demographics; Epidemiology; IgG antibody; Immunoglobulin G; Males; Older people; Quality assurance; Risk factors; Schistosoma; Schistosomiasis; Serology; Sex; Sexual behavior; Soluble egg antigen; Statistical analysis; Surveys; Senegal; Schistosomiasis; Serology; Schistosoma egg extract; Senegal; Nomadic pastoralist
• DOI: 10.1645/22-69
• ISSN: 0022-3395; 1937-2345

Urinary and intestinal schistosomiasis are endemic in Senegal, with prevalence heterogeneous throughout the country. Because of their way of life, nomadic pastoralists are not typically included in epidemiological surveys, and data on the prevalence of schistosomiasis in Senegalese nomadic populations are largely non-existent. The purpose of this study was to determine the seroprevalence of schistosomiasis in Senegalese nomadic pastoralists. A modified snowball sampling survey was conducted among 1,467 nomadic pastoralists aged 6 mo and older in 5 districts in northern Senegal. Dried blood spots from participants of all ages and data regarding demographics were collected to assess IgG antibody responses against Schistosoma mansoni soluble egg antigen (SEA) using a bead-based multiplex assay. Out of 1,467 study subjects, 1,464 (99.8%) provided IgG serological data that cleared quality assurance. Of the participants with appropriate data, 56.6% were male, the median age was 22 yr, and 31.6% were under 15 yr of age. The overall anti-SEA IgG seroprevalence was 19.1% (95% confidence interval [CI]: 17.1-21.1%) with the highest estimates observed in Dagana (35.9%) and the lowest observed in Podor nomadic groups (3.4%). Antibody responses increased significantly with age except for the oldest age groups (>40 yr of age), which saw lower levels of antibody response compared to younger adults. When controlling for age and location by multivariate regression, the male sex was associated with a 2-fold greater odds of anti-SEA IgG seropositivity (aPOR: 2.0; 95% CI: 1.5-2.7). Serosurveys for anti-SEA IgG among nomadic peoples in northern Senegal found a substantial percentage of individuals with evidence for current or previous Schistosoma spp. infection with the highest levels of exposure in the district adjacent to the Diama dam along the Senegal River. With IgG prevalence increased by age except in the older adults, and the male sex significantly associated with seropositivity, these data point toward sex-associated behavioral practices and human environmental modification as risk factors for Schistosoma exposure.