Inhibition effect of arachidonic acid on hypoxia-induced [Ca2+ ] i elevation in PC12 cells and human pulmonary artery smooth muscle cells

• Published in: Respiratory physiology & neurobiology Vol. 162; no. 1; pp. 18 - 23
• Main Authors: Meng, Fei, To, Wilson King Lim, Gu, Yuchun
• Format: Journal Article
• Language: English
• Published: Amsterdarm Elsevier B.V 2008; Elsevier
• Subjects: Arachidonic acid; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Human pulmonary artery smooth muscle cell; Hypoxia; Intracellular Ca 2; Medical Education; PC12; Pulmonary/Respiratory; Vertebrates: respiratory system; PC12; Hypoxia; Human pulmonary artery smooth muscle cell; Arachidonic acid; Intracellular Ca 2; Human; Oxygen; Calcium; Smooth muscle; Inorganic element; Respiratory system; In vitro; Pulmonary artery; Vertebrata; Cell line; Mammalia; Neuron; Pulmonary vessel; Blood vessel; Circulatory system; Inhibition; Intracellular; Intracellular Ca2

Abstract [Ca2+ ] i elevation is a key event when O2 sensitive cells, e.g. PC12 cells and pulmonary artery smooth muscle cells, face hypoxia. Ca2+ entry pathways in mediating hypoxia-induced [Ca2+ ] i elevation include: voltage-gated Ca2+ channels (VGCCs), transient receptor potential (TRP) channel a...