Aronia melanocarpa Elliot anthocyanins inhibit colon cancer by regulating glutamine metabolism

• Published in: Food bioscience Vol. 40; p. 100910
• Main Authors: Yu, Wenchen, Gao, Jun, Hao, Ruobing, Zhang, Chenjuan, Liu, Hongwei, Fan, Jungang, Wei, Jie
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.04.2021
• Subjects: Aronia melanocarpa Elliot anthocyanins; Colorectal cancer; Glutamine; SLC1A5; PBS; RNA; DMSO; DSS; Colorectal cancer; Gln; GDH; SLC1A5; EDTA; GLS; Aronia melanocarpa Elliot anthocyanins; CCK8; TCA; FBS; DNA; mTOR; ATP; Glutamine; AOM

An azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model and the Caco-2 cell line were used to evaluate the therapeutic effects and mechanisms of Aornia melanocarpa Elliot anthocyanins (AMA) in colitis-associated colorectal cancer (CRC). In this study, AMA could significantly inhibit the proli...