In Vitro Cell Culture Models of Hyperoxaluric States: Calcium Oxalate and Renal Epithelial Cell Interactions

Urolithiasis is a multifactorial disease with a high incidence and high recurrence rate, characterized by formation of solid deposits in the urinary tract. The most common type of these stones are calcium oxalate stones. Calcium oxalate crystals can, in hyperoxaluric states, interact with renal epit...

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Published inCrystals (Basel) Vol. 11; no. 7; p. 735
Main Authors Petrović, Ana, Kizivat, Tomislav, Bilić Ćurčić, Ines, Smolić, Robert, Smolić, Martina
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.07.2021
Subjects
antioxidants
Apoptosis
Autophagy
Calcium
calcium oxalate
Calculi
Cell adhesion & migration
Cell culture
Crystallization
Cytotoxicity
Disease
Epithelium
Gene expression
hyperoxaluria
Kidney stones
Morphology
Oxidative stress
Pathogenesis
Proteins
Urine
Urolithiasis
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Abstract Urolithiasis is a multifactorial disease with a high incidence and high recurrence rate, characterized by formation of solid deposits in the urinary tract. The most common type of these stones are calcium oxalate stones. Calcium oxalate crystals can, in hyperoxaluric states, interact with renal epithelial cells, causing injury to the renal epithelia. Pathogenesis of urolithiasis is widely investigated, but underlying mechanisms are still not completely clarified. In vitro models offer insight into molecular processes which lead to renal stone formation and are significant for evaluation of prophylactic and therapeutic management of patients with urolithiasis. In this review, we summarize recently published data from in vitro studies investigating interactions of calcium oxalate crystals with renal epithelial cell lines, anti-urolithiatic mechanisms, and the results from studies exploring possible therapeutic and prophylactic options for calcium oxalate urolithiasis in cell cultures.
AbstractList Urolithiasis is a multifactorial disease with a high incidence and high recurrence rate, characterized by formation of solid deposits in the urinary tract. The most common type of these stones are calcium oxalate stones. Calcium oxalate crystals can, in hyperoxaluric states, interact with renal epithelial cells, causing injury to the renal epithelia. Pathogenesis of urolithiasis is widely investigated, but underlying mechanisms are still not completely clarified. In vitro models offer insight into molecular processes which lead to renal stone formation and are significant for evaluation of prophylactic and therapeutic management of patients with urolithiasis. In this review, we summarize recently published data from in vitro studies investigating interactions of calcium oxalate crystals with renal epithelial cell lines, anti-urolithiatic mechanisms, and the results from studies exploring possible therapeutic and prophylactic options for calcium oxalate urolithiasis in cell cultures.
Author Petrović, Ana
Kizivat, Tomislav
Smolić, Martina
Bilić Ćurčić, Ines
Smolić, Robert
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crossref_primary_10_3390_cryst11101243
crossref_primary_10_3390_cryst13071070
crossref_primary_10_1016_j_bcab_2023_102837
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Snippet Urolithiasis is a multifactorial disease with a high incidence and high recurrence rate, characterized by formation of solid deposits in the urinary tract. The...
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SubjectTerms antioxidants
Apoptosis
Autophagy
Calcium
calcium oxalate
Calculi
Cell adhesion & migration
Cell culture
Crystallization
Cytotoxicity
Disease
Epithelium
Gene expression
hyperoxaluria
Kidney stones
Morphology
Oxidative stress
Pathogenesis
Proteins
Urine
Urolithiasis
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Title In Vitro Cell Culture Models of Hyperoxaluric States: Calcium Oxalate and Renal Epithelial Cell Interactions
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