Hemoglobin and myoglobin stabilization by heme-fluoride complexes

• Published in: Polyhedron Vol. 203; p. 115238
• Main Authors: Flanders, Kayla G., Pessagno, Lucie R., Cerda, Jose F.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 15.07.2021
• Subjects: Fluoride binding; Hemoglobin; Iron protoporphyrin IX; Myoglobin; Protein denaturation; Myoglobin; Hemoglobin; Protein denaturation; Iron protoporphyrin IX; Fluoride binding

Native ferric hemoglobin and myoglobin are up to 50% more stable as heme-fluoride complexes under guanidine-HCl and acidic denaturing conditions. [Display omitted] Under physiological conditions, hemoglobin (Hb) and myoglobin (Mb) are subject to autoxidation, leading to the formation of ferric heme...