Correlation Between C-Reactive Protein and Lipid Analytes in Dry Age-Related Macular Degeneration: A Retrospective Study

To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD) patients, often reporting conflicting findings. This study aimed to investigate the correlation between lipid analytes and C-reactive protein (CR...

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Published inCurēus (Palo Alto, CA) Vol. 16; no. 1; p. e51935
Main Authors Sannan, Naif S, Elsayid, Mohieldin, Alsharif, Ghadi, Ramadan, Majed, Alhalwani, Amani Y, Qahwaji, Rowaid M, Arbaeen, Ahmad, Aalam, Waseem A, Alqahtani, Abdullah S, Talat, Karim
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 09.01.2024
Cureus
Subjects
Analysis of covariance
Biomarkers
High density lipoprotein
Inflammation
Lipids
Macular degeneration
Older people
Ophthalmology
Saudi Arabia
crp
dry age-related macular degeneration
inflammation
lipid profile
serum biomarkers
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Abstract To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD) patients, often reporting conflicting findings. This study aimed to investigate the correlation between lipid analytes and C-reactive protein (CRP) levels in individuals diagnosed with dry AMD. A standard clinical lipid panel (total cholesterol, triglycerides, high-density lipoprotein [HDL], and low-density lipoproteins) and CRP laboratory results were retrospectively collected from the medical records of patients with dry AMD and age- and sex-matched controls. The study included 90 patients with dry AMD and 270 patients without AMD. In univariate analysis, CRP showed a higher mean value in cases than in controls. After adjusting for age and sex, CRP and triglyceride levels showed significant differences between cases and controls. Pearson's correlation analysis revealed a significant negative correlation between CRP and HDL levels in the dry AMD group (n=90). Other lipid analytes showed no significant correlations with CRP. Our findings add to the growing body of evidence linking inflammation to AMD. Although it is unclear whether changes in serum CRP and triglyceride levels are the causes or effects, monitoring both analytes may be beneficial as an early disease predictor, especially in individuals with a family history of AMD. The negative correlation between CRP and HDL (i.e., inflammation and good cholesterol) may be targeted for future therapies.
AbstractList Introduction: To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD) patients, often reporting conflicting findings. This study aimed to investigate the correlation between lipid analytes and C-reactive protein (CRP) levels in individuals diagnosed with dry AMD.Methods: A standard clinical lipid panel (total cholesterol, triglycerides, high-density lipoprotein [HDL], and low-density lipoproteins) and CRP laboratory results were retrospectively collected from the medical records of patients with dry AMD and age- and sex-matched controls.Results: The study included 90 patients with dry AMD and 270 patients without AMD. In univariate analysis, CRP showed a higher mean value in cases than in controls. After adjusting for age and sex, CRP and triglyceride levels showed significant differences between cases and controls. Pearson’s correlation analysis revealed a significant negative correlation between CRP and HDL levels in the dry AMD group (n=90). Other lipid analytes showed no significant correlations with CRP.Conclusion: Our findings add to the growing body of evidence linking inflammation to AMD. Although it is unclear whether changes in serum CRP and triglyceride levels are the causes or effects, monitoring both analytes may be beneficial as an early disease predictor, especially in individuals with a family history of AMD. The negative correlation between CRP and HDL (i.e., inflammation and good cholesterol) may be targeted for future therapies.
Introduction: To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD) patients, often reporting conflicting findings. This study aimed to investigate the correlation between lipid analytes and C-reactive protein (CRP) levels in individuals diagnosed with dry AMD. Methods: A standard clinical lipid panel (total cholesterol, triglycerides, high-density lipoprotein [HDL], and low-density lipoproteins) and CRP laboratory results were retrospectively collected from the medical records of patients with dry AMD and age- and sex-matched controls. Results: The study included 90 patients with dry AMD and 270 patients without AMD. In univariate analysis, CRP showed a higher mean value in cases than in controls. After adjusting for age and sex, CRP and triglyceride levels showed significant differences between cases and controls. Pearson’s correlation analysis revealed a significant negative correlation between CRP and HDL levels in the dry AMD group (n=90). Other lipid analytes showed no significant correlations with CRP. Conclusion: Our findings add to the growing body of evidence linking inflammation to AMD. Although it is unclear whether changes in serum CRP and triglyceride levels are the causes or effects, monitoring both analytes may be beneficial as an early disease predictor, especially in individuals with a family history of AMD. The negative correlation between CRP and HDL (i.e., inflammation and good cholesterol) may be targeted for future therapies.
To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD) patients, often reporting conflicting findings. This study aimed to investigate the correlation between lipid analytes and C-reactive protein (CRP) levels in individuals diagnosed with dry AMD. A standard clinical lipid panel (total cholesterol, triglycerides, high-density lipoprotein [HDL], and low-density lipoproteins) and CRP laboratory results were retrospectively collected from the medical records of patients with dry AMD and age- and sex-matched controls. The study included 90 patients with dry AMD and 270 patients without AMD. In univariate analysis, CRP showed a higher mean value in cases than in controls. After adjusting for age and sex, CRP and triglyceride levels showed significant differences between cases and controls. Pearson's correlation analysis revealed a significant negative correlation between CRP and HDL levels in the dry AMD group (n=90). Other lipid analytes showed no significant correlations with CRP. Our findings add to the growing body of evidence linking inflammation to AMD. Although it is unclear whether changes in serum CRP and triglyceride levels are the causes or effects, monitoring both analytes may be beneficial as an early disease predictor, especially in individuals with a family history of AMD. The negative correlation between CRP and HDL (i.e., inflammation and good cholesterol) may be targeted for future therapies.
INTRODUCTIONTo date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD) patients, often reporting conflicting findings. This study aimed to investigate the correlation between lipid analytes and C-reactive protein (CRP) levels in individuals diagnosed with dry AMD.METHODSA standard clinical lipid panel (total cholesterol, triglycerides, high-density lipoprotein [HDL], and low-density lipoproteins) and CRP laboratory results were retrospectively collected from the medical records of patients with dry AMD and age- and sex-matched controls.RESULTSThe study included 90 patients with dry AMD and 270 patients without AMD. In univariate analysis, CRP showed a higher mean value in cases than in controls. After adjusting for age and sex, CRP and triglyceride levels showed significant differences between cases and controls. Pearson's correlation analysis revealed a significant negative correlation between CRP and HDL levels in the dry AMD group (n=90). Other lipid analytes showed no significant correlations with CRP.CONCLUSIONOur findings add to the growing body of evidence linking inflammation to AMD. Although it is unclear whether changes in serum CRP and triglyceride levels are the causes or effects, monitoring both analytes may be beneficial as an early disease predictor, especially in individuals with a family history of AMD. The negative correlation between CRP and HDL (i.e., inflammation and good cholesterol) may be targeted for future therapies.
Author Ramadan, Majed
Sannan, Naif S
Aalam, Waseem A
Alqahtani, Abdullah S
Alhalwani, Amani Y
Alsharif, Ghadi
Arbaeen, Ahmad
Talat, Karim
Elsayid, Mohieldin
Qahwaji, Rowaid M
AuthorAffiliation 6 Department of Ophthalmology, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Jeddah, SAU
1 Department of Clinical Laboratory Sciences, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU
2 Department of Biomedical Research, King Abdullah International Medical Research Center, Jeddah, SAU
4 Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, SAU
3 Department of Clinical Laboratory, King Abdulaziz University, Jeddah, SAU
5 Department of Ophthalmology, College of Medicine, University of Jeddah, Jeddah, SAU
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Cites_doi 10.1016/S2214-109X(13)70145-1
10.3109/07853890009011772
10.1001/archopht.123.6.774
10.1167/iovs.09-4063
10.1038/eye.2011.56
10.1111/opo.12675
10.1016/s0304-3835(99)00424-3
10.1016/j.ophtha.2018.09.045
10.4172/2155-6156.1000109
10.1016/j.jacl.2015.10.002
10.3389/fmed.2023.1143045
10.1186/s12944-016-0262-z
10.1016/j.ajo.2003.09.015
10.1001/jama.1994.03520180037032
10.1001/archopht.118.3.351
10.1016/j.optom.2013.07.002
10.1001/jama.1996.03540140029022
10.3390/nu8100663
10.1016/S0140-6736(18)31550-2
10.1093/ije/dyx189
10.1001/archopht.119.8.1191
10.1001/jamaophthalmol.2013.2303
10.2174/1874364101913010090
10.1001/jama.291.6.704
10.2174/0929867321666140414103455
10.1016/j.preteyeres.2009.08.001
10.1371/journal.pone.0090973
10.1371/journal.pone.0091080
10.1016/j.oret.2020.01.012
10.1167/tvst.10.12.7
10.1167/iovs.19-27325
10.1016/S0161-6420(03)00599-2
10.1167/iovs.05-0034
10.1001/archopht.121.6.785
10.1016/S0161-6420(00)00580-7
10.1080/09273948.2022.2092752
10.1186/s12944-018-0954-7
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Keywords crp
dry age-related macular degeneration
inflammation
lipid profile
serum biomarkers
Language English
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References Colijn JM (ref14) 2019; 126
Seddon JM (ref20) 2005; 123
Ngai LY (ref8) 2011; 25
Heesterbeek TJ (ref4) 2020; 40
Salimiaghdam N (ref7) 2019; 13
Sannan NS (ref22) 2023; 10
Cougnard-Grégoire A (ref25) 2014; 9
Brown WV (ref31) 2016; 10
Semba RD (ref13) 2019; 18
Chen RC (ref19) 2021; 10
Mousavi M (ref3) 2013; 6
Calle MC (ref29) 2010; 1
Davari MH (ref12) 2013; 13
Armstrong RA (ref5) 2015; 10
Van Leeuwen R (ref11) 2004; 137
Mitta VP (ref27) 2013; 131
Rizzo M (ref33) 2014; 21
Seddon JM (ref37) 2003; 121
Mao F (ref16) 2019; 60
Chi PD (ref30) 2014; 9
Hyman L (ref9) 2000; 118
Wang Y (ref15) 2016; 8
Boey PY (ref32) 2010; 51
Seddon JM (ref34) 1996; 276
Seddon JM (ref35) 1994; 272
Klein R (ref10) 2003; 110
Matsui A (ref24) 2000; 151
Fan Q (ref26) 2017; 46
Wong WL (ref1) 2014; 2
Chakravarthy U (ref38) 2020; 4
Smith W (ref6) 2001; 108
Du Clos TW (ref17) 2000; 32
Naif S (ref21) 2023; 31
Seddon JM (ref36) 2001; 119
Li CM (ref23) 2005; 46
Wu S (ref28) 2016; 15
Curcio CA (ref39) 2009; 28
Mitchell P (ref2) 2018; 392
Seddon JM (ref18) 2004; 291
References_xml – volume: 2
  year: 2014
  ident: ref1
  article-title: Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis
  publication-title: Lancet Glob Heal
  doi: 10.1016/S2214-109X(13)70145-1
  contributor:
    fullname: Wong WL
– volume: 32
  year: 2000
  ident: ref17
  article-title: Function of C-reactive protein
  publication-title: Ann Med
  doi: 10.3109/07853890009011772
  contributor:
    fullname: Du Clos TW
– volume: 123
  year: 2005
  ident: ref20
  article-title: Progression of age-related macular degeneration: Prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.123.6.774
  contributor:
    fullname: Seddon JM
– volume: 51
  year: 2010
  ident: ref32
  article-title: C-reactive protein and age-related macular degeneration and cataract: The Singapore Malay Eye Study
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.09-4063
  contributor:
    fullname: Boey PY
– volume: 25
  year: 2011
  ident: ref8
  article-title: The prevalence and analysis of risk factors for age-related macular degeneration: 18-year follow-up data from the Speedwell eye study, United Kingdom
  publication-title: Eye (Lond)
  doi: 10.1038/eye.2011.56
  contributor:
    fullname: Ngai LY
– volume: 40
  year: 2020
  ident: ref4
  article-title: Risk factors for progression of age-related macular degeneration
  publication-title: Ophthalmic Physiol Opt
  doi: 10.1111/opo.12675
  contributor:
    fullname: Heesterbeek TJ
– volume: 151
  year: 2000
  ident: ref24
  article-title: Increased formation of oxidative DNA damage, 8-hydroxy-2’-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes
  publication-title: Cancer Lett
  doi: 10.1016/s0304-3835(99)00424-3
  contributor:
    fullname: Matsui A
– volume: 126
  year: 2019
  ident: ref14
  article-title: Increased high-density lipoprotein levels associated with age-related macular degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2018.09.045
  contributor:
    fullname: Colijn JM
– volume: 1
  year: 2010
  ident: ref29
  article-title: Low plasma Hdl cholesterol and elevated C reactive protein further increase cardiovascular disease risk in Latinos with type 2 diabetes
  publication-title: J Diabetes Metab
  doi: 10.4172/2155-6156.1000109
  contributor:
    fullname: Calle MC
– volume: 10
  year: 2016
  ident: ref31
  article-title: Inverse relationship between high-density lipoprotein cholesterol raising and high-sensitivity C-reactive protein reduction in older patients treated with lipid-lowering therapy
  publication-title: J Clin Lipidol
  doi: 10.1016/j.jacl.2015.10.002
  contributor:
    fullname: Brown WV
– volume: 10
  year: 2023
  ident: ref22
  article-title: Assessment of aggregate index of systemic inflammation and systemic inflammatory response index in dry age-related macular degeneration: A retrospective study
  publication-title: Front Med (Lausanne)
  doi: 10.3389/fmed.2023.1143045
  contributor:
    fullname: Sannan NS
– volume: 15
  year: 2016
  ident: ref28
  article-title: Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population
  publication-title: Lipids Health Dis
  doi: 10.1186/s12944-016-0262-z
  contributor:
    fullname: Wu S
– volume: 137
  year: 2004
  ident: ref11
  article-title: Cholesterol and age-related macular degeneration: Is there a link?
  publication-title: Am J Ophthalmol
  doi: 10.1016/j.ajo.2003.09.015
  contributor:
    fullname: Van Leeuwen R
– volume: 272
  year: 1994
  ident: ref35
  article-title: Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group
  publication-title: JAMA
  doi: 10.1001/jama.1994.03520180037032
  contributor:
    fullname: Seddon JM
– volume: 118
  year: 2000
  ident: ref9
  article-title: Hypertension, cardiovascular disease, and age-related macular degeneration. Age-Related Macular Degeneration Risk Factors Study Group
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.118.3.351
  contributor:
    fullname: Hyman L
– volume: 6
  year: 2013
  ident: ref3
  article-title: Genetic risk factors and age-related macular degeneration (AMD)
  publication-title: J Optom
  doi: 10.1016/j.optom.2013.07.002
  contributor:
    fullname: Mousavi M
– volume: 276
  year: 1996
  ident: ref34
  article-title: A prospective study of cigarette smoking and age-related macular degeneration in women
  publication-title: JAMA
  doi: 10.1001/jama.1996.03540140029022
  contributor:
    fullname: Seddon JM
– volume: 8
  year: 2016
  ident: ref15
  article-title: The association between the lipids levels in blood and risk of age-related macular degeneration
  publication-title: Nutrients
  doi: 10.3390/nu8100663
  contributor:
    fullname: Wang Y
– volume: 392
  year: 2018
  ident: ref2
  article-title: Age-related macular degeneration
  publication-title: Lancet
  doi: 10.1016/S0140-6736(18)31550-2
  contributor:
    fullname: Mitchell P
– volume: 46
  year: 2017
  ident: ref26
  article-title: HDL-cholesterol levels and risk of age-related macular degeneration: A multiethnic genetic study using Mendelian randomization
  publication-title: Int J Epidemiol
  doi: 10.1093/ije/dyx189
  contributor:
    fullname: Fan Q
– volume: 10
  year: 2015
  ident: ref5
  article-title: Overview of risk factors for age-related macular degeneration (AMD)
  publication-title: J Stem Cells
  contributor:
    fullname: Armstrong RA
– volume: 119
  year: 2001
  ident: ref36
  article-title: Dietary fat and risk for advanced age-related macular degeneration
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.119.8.1191
  contributor:
    fullname: Seddon JM
– volume: 131
  year: 2013
  ident: ref27
  article-title: C-reactive protein and the incidence of macular degeneration: Pooled analysis of 5 cohorts
  publication-title: JAMA Ophthalmol
  doi: 10.1001/jamaophthalmol.2013.2303
  contributor:
    fullname: Mitta VP
– volume: 13
  year: 2019
  ident: ref7
  article-title: Age-related macular degeneration (AMD): A review on its epidemiology and risk factors
  publication-title: Open Ophthalmol J
  doi: 10.2174/1874364101913010090
  contributor:
    fullname: Salimiaghdam N
– volume: 291
  year: 2004
  ident: ref18
  article-title: Association between C-reactive protein and age-related macular degeneration
  publication-title: JAMA
  doi: 10.1001/jama.291.6.704
  contributor:
    fullname: Seddon JM
– volume: 21
  year: 2014
  ident: ref33
  article-title: Subfractions and subpopulations of HDL: An update
  publication-title: Curr Med Chem
  doi: 10.2174/0929867321666140414103455
  contributor:
    fullname: Rizzo M
– volume: 28
  year: 2009
  ident: ref39
  article-title: Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins
  publication-title: Prog Retin Eye Res
  doi: 10.1016/j.preteyeres.2009.08.001
  contributor:
    fullname: Curcio CA
– volume: 9
  year: 2014
  ident: ref25
  article-title: Elevated high-density lipoprotein cholesterol and age-related macular degeneration: The Alienor study
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0090973
  contributor:
    fullname: Cougnard-Grégoire A
– volume: 9
  year: 2014
  ident: ref30
  article-title: High-density lipoprotein cholesterol is a favorable prognostic factor and negatively correlated with C-reactive protein level in non-small cell lung carcinoma
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0091080
  contributor:
    fullname: Chi PD
– volume: 4
  year: 2020
  ident: ref38
  article-title: Progression from early/intermediate to advanced forms of age-related macular degeneration in a large UK cohort: Rates and risk factors
  publication-title: Ophthalmol Retina
  doi: 10.1016/j.oret.2020.01.012
  contributor:
    fullname: Chakravarthy U
– volume: 13
  year: 2013
  ident: ref12
  article-title: Correlation between serum lipids and age-related macular degeneration: A case-control study
  publication-title: J Res Health Sci
  contributor:
    fullname: Davari MH
– volume: 10
  year: 2021
  ident: ref19
  article-title: Increased systemic C-reactive protein is associated with choroidal thinning in intermediate age-related macular degeneration
  publication-title: Transl Vis Sci Technol
  doi: 10.1167/tvst.10.12.7
  contributor:
    fullname: Chen RC
– volume: 60
  year: 2019
  ident: ref16
  article-title: Six-year incidence and risk factors for age-related macular degeneration in a rural Chinese population: The Handan Eye Study
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.19-27325
  contributor:
    fullname: Mao F
– volume: 110
  year: 2003
  ident: ref10
  article-title: The association of cardiovascular disease with the long-term incidence of age-related maculopathy: The Beaver Dam Eye Study
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(03)00599-2
  contributor:
    fullname: Klein R
– volume: 46
  year: 2005
  ident: ref23
  article-title: Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: Initial characterization
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.05-0034
  contributor:
    fullname: Li CM
– volume: 121
  year: 2003
  ident: ref37
  article-title: Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.121.6.785
  contributor:
    fullname: Seddon JM
– volume: 108
  year: 2001
  ident: ref6
  article-title: Risk factors for age-related macular degeneration: Pooled findings from three continents
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(00)00580-7
  contributor:
    fullname: Smith W
– volume: 31
  year: 2023
  ident: ref21
  article-title: Neutrophil-lymphocyte ratios in dry age-related macular degeneration
  publication-title: Ocul Immunol Inflamm
  doi: 10.1080/09273948.2022.2092752
  contributor:
    fullname: Naif S
– volume: 18
  year: 2019
  ident: ref13
  article-title: Serum lipids in adults with late age-related macular degeneration: A case-control study
  publication-title: Lipids Health Dis
  doi: 10.1186/s12944-018-0954-7
  contributor:
    fullname: Semba RD
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Snippet To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular degeneration (AMD)...
Introduction: To date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular...
INTRODUCTIONTo date few studies have investigated the correlation between inflammatory markers and lipoproteins in the serum of age-related macular...
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StartPage e51935
SubjectTerms Analysis of covariance
Biomarkers
High density lipoprotein
Inflammation
Lipids
Macular degeneration
Older people
Ophthalmology
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Title Correlation Between C-Reactive Protein and Lipid Analytes in Dry Age-Related Macular Degeneration: A Retrospective Study
URI https://www.ncbi.nlm.nih.gov/pubmed/38333436
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Volume 16
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