The rs2175898 Polymorphism in the ESR1 Gene has a Significant Sex-Specific Effect on Obesity

• Published in: Biochemical genetics Vol. 58; no. 6; pp. 935 - 952
• Main Authors: Guclu-Geyik, Filiz, Coban, Neslihan, Can, Gunay, Erginel-Unaltuna, Nihan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2020; Springer Nature B.V
• Subjects: age; alleles; Biochemistry; Biomedical and Life Sciences; Biomedicine; blood serum; Body mass index; Body size; Diabetes mellitus; elderly; ESR1 protein; females; Gene polymorphism; genetic polymorphism; genotype; Genotype & phenotype; Genotypes; genotyping; Human Genetics; Hybridization; hybridization probes; Lipid metabolism; Lipids; males; Medical Microbiology; Men; Menopause; Obesity; Original Article; phenotype; Phenotypes; Physical activity; Polymerase chain reaction; Polymorphism; prevalence; quantitative polymerase chain reaction; Regression analysis; Risk reduction; Sex; Sex differences; smoking (habit); waist circumference; Women; Zoology; Obesity; gene polymorphism; Sex-specific effect; TARF study; BMI

Polymorphisms in the ESR1 gene have been associated with obesity and lipid metabolism. There are also important sex-related differences in the prevalence of obesity and related phenotypes. Therefore, we aimed to interrogate the association of the ESR1 rs2175898 gene polymorphism with obesity, obesit...