Efficacy of Solifenacin on Overactive Bladder Symptoms, Symptom Bother, and Other Patient-Reported Outcomes in Subjects With or Without Incontinence: A Post Hoc Analysis of Data From VIBRANT
: To evaluate the efficacy of solifenacin versus placebo by baseline continence status using post hoc analysis. : Patients with overactive bladder (OAB) were randomized to solifenacin or placebo for 12 weeks; patient-reported outcome (PRO) measures and bladder diaries were completed at prespecified...
Saved in:
Published in | Female pelvic medicine & reconstructive surgery Vol. 17; no. 1; p. 24 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.01.2011
|
Online Access | Get more information |
Cover
Loading…
Abstract | : To evaluate the efficacy of solifenacin versus placebo by baseline continence status using post hoc analysis.
: Patients with overactive bladder (OAB) were randomized to solifenacin or placebo for 12 weeks; patient-reported outcome (PRO) measures and bladder diaries were completed at prespecified time points. VESIcare Investigation of Bother and Quality of Life in Subjects with OAB (VIBRANT) was not designed to show treatment differences within continence status subgroups.
: In the full analysis set (n = 750), 73% of patients were incontinent (n = 545) at baseline. After 12 weeks, incontinent patients receiving solifenacin showed significant improvements versus placebo on PRO measures and most diary-based end points; continent patients (n = 205) showed smaller but similar treatment-related changes. Tolerability was similar in both subgroups and by treatment; most frequent adverse events were dry mouth and constipation.
: In the VIBRANT study, solifenacin significantly improved OAB symptom bother, health-related quality of life, and most symptoms versus placebo in incontinent patients. Continent patients showed smaller but similar trends. Solifenacin was well tolerated in both subgroups. |
---|---|
AbstractList | : To evaluate the efficacy of solifenacin versus placebo by baseline continence status using post hoc analysis.
: Patients with overactive bladder (OAB) were randomized to solifenacin or placebo for 12 weeks; patient-reported outcome (PRO) measures and bladder diaries were completed at prespecified time points. VESIcare Investigation of Bother and Quality of Life in Subjects with OAB (VIBRANT) was not designed to show treatment differences within continence status subgroups.
: In the full analysis set (n = 750), 73% of patients were incontinent (n = 545) at baseline. After 12 weeks, incontinent patients receiving solifenacin showed significant improvements versus placebo on PRO measures and most diary-based end points; continent patients (n = 205) showed smaller but similar treatment-related changes. Tolerability was similar in both subgroups and by treatment; most frequent adverse events were dry mouth and constipation.
: In the VIBRANT study, solifenacin significantly improved OAB symptom bother, health-related quality of life, and most symptoms versus placebo in incontinent patients. Continent patients showed smaller but similar trends. Solifenacin was well tolerated in both subgroups. |
Author | Forero-Schwanhaeuser, Sergio Vardy, Michael D Samuels, Terri-Ann He, Weizhong Mitcheson, H David |
Author_xml | – sequence: 1 givenname: Michael D surname: Vardy fullname: Vardy, Michael D organization: From the Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, Riverdale, NY; †Englewood Hospital, Englewood, NJ; ‡Bay State Clinical Trials, Inc, Watertown, MA; §Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine, New York, NY; ∥GlaxoSmithKline, King of Prussia, PA; and ¶Astellas Pharma US, Inc, Deerfield, IL – sequence: 2 givenname: H David surname: Mitcheson fullname: Mitcheson, H David – sequence: 3 givenname: Terri-Ann surname: Samuels fullname: Samuels, Terri-Ann – sequence: 4 givenname: Sergio surname: Forero-Schwanhaeuser fullname: Forero-Schwanhaeuser, Sergio – sequence: 5 givenname: Weizhong surname: He fullname: He, Weizhong |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22453669$$D View this record in MEDLINE/PubMed |
BookMark | eNo1kNlOKzEQRC3EFfsfINQfwHC9zcZbwhoJ3USE5RF52m1hlLGjsYOUn-PbCHDplzqqh6pW7bPtEAMxdiz4meBt_Xc-ezrjHReKlGgk17KV7Rbbk6LUhZZCbn-zKBpVN7vsKKU3vjnVNGWpd9iulLpUVdXusY8r5zwaXEN0MI8L7ygY9AFigOk7DQazfycYL4y1NMB83S9z7NPpL8E45lcaTsEEC9MvhJnJnkIu7mkZh0wbe5Ux9pRgEztfdW-EOcGzz68Qh2-NqwyTgDFkHyggncMIZjFluI0Io2AW6-TT14OXJhu4Hja1T5Px_ejfwyH748wi0dF_PWCP11cPF7fF3fRmcjG6K1BxXha6E52rpC2FrjlKi5rQCdvWTd02pVYotRaWV0qi1eiwxtaRLEVXtcpp4eQBO_nJXa66nuzLcvC9GdYvv0PKT8euevo |
ContentType | Journal Article |
DBID | NPM |
DOI | 10.1097/SPV.0b013e3182042929 |
DatabaseName | PubMed |
DatabaseTitle | PubMed |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
EISSN | 2154-4212 |
ExternalDocumentID | 22453669 |
Genre | Journal Article |
GroupedDBID | --- .XZ .Z2 0R~ 53G 5VS 8L- AAAAV AAHPQ AAIQE AAJCS AARTV AASCR ABASU ABBUW ABDIG ABJNI ABVCZ ABXVJ ABZAD ACDDN ACEWG ACGFS ACILI ACWDW ACWRI ACXJB ACXNZ ADGGA ADHPY ADNKB AEBDS AEETU AENEX AFDTB AFEXH AHQNM AHVBC AINUH AJIOK AJNWD AJNYG ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BQLVK C45 DIWNM DUNZO E.X EBS EEVPB EJD EX3 F5P FCALG FL- GNXGY GQDEL HLJTE HZ~ IKREB IN~ K-A K-F KD2 L-C NPM O9- ODMTH OHYEH OPUJH OUVQU OVD OVDNE OXXIT RLZ S4S TEORI TSPGW W3M WOW ZZMQN |
ID | FETCH-LOGICAL-c3005-4b1bf62d51470c2dc4ecf1d978798543c2441d0632cd4cfc7c9fe251b693f41f2 |
ISSN | 2151-8378 |
IngestDate | Thu May 23 23:17:40 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c3005-4b1bf62d51470c2dc4ecf1d978798543c2441d0632cd4cfc7c9fe251b693f41f2 |
PMID | 22453669 |
ParticipantIDs | pubmed_primary_22453669 |
PublicationCentury | 2000 |
PublicationDate | 2011-Jan |
PublicationDateYYYYMMDD | 2011-01-01 |
PublicationDate_xml | – month: 01 year: 2011 text: 2011-Jan |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Female pelvic medicine & reconstructive surgery |
PublicationTitleAlternate | Female Pelvic Med Reconstr Surg |
PublicationYear | 2011 |
SSID | ssj0000388554 |
Score | 1.8538382 |
Snippet | : To evaluate the efficacy of solifenacin versus placebo by baseline continence status using post hoc analysis.
: Patients with overactive bladder (OAB) were... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 24 |
Title | Efficacy of Solifenacin on Overactive Bladder Symptoms, Symptom Bother, and Other Patient-Reported Outcomes in Subjects With or Without Incontinence: A Post Hoc Analysis of Data From VIBRANT |
URI | https://www.ncbi.nlm.nih.gov/pubmed/22453669 |
Volume | 17 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1Lb9NAEIBXDVy4IBDvl-bALV1I4ucicUigKCC1QaQtvVXe9W4JSuwoJELw4_htzOwjcUOQChfHsaWN7f0yMzueB2PPhVQZqXmeSqE4dTniIhKay05XdaQo8iinBOfDo3R4En84S872Wp1G1NJqKV-onzvzSv5nVvEYzitlyf7DzK4HxQO4j_OLW5xh3F5pjg-o_gP1a7eZJ9OJ0VWhJhW9ABjhzRRWlrUHU5Iui_b4x2y-rJ1rxe-3BzYBK4RwjugLVe2nJEnubHM0SEerJV69jdwiQfPVBoB8JgduvbCfFNuMgqamrhMkKVy6O_UBbg9rdanwydtiWaC1jD99-n7wqe8bCYQ-oXqG-qo911OUX-vX_pZOu3D3xW7xnr41srltuzAff-CzADZxzIcTwtKnlQ2bIfyr1-NitkLTwCJLBSp5v1r_Vahl6aLmY_Xle1HhkOTMsQ9OLy5c6FrwldiMweArsSKV7BtOJfSd9gvHYk7vxS_phOwP9r2Aj3fqHVfPePzxdONY7pGqd96cBorzmWURDackStMrnN2qBh5OtVgry0miH3nvlLU8opyiDqmfYrjRkC0qspe7ro5qYfsRt9ZV1r46vsVu-oUR9B3lt9meru6wX4FwqA00CIe6gg3h4AmHQPh-2APH9z4g3WDphm26IdANOGygG4hqqBfg6YYm3a-gD8Q2INsQ2KYLJLaB2AbP9l128u7g-M2Q-44jXFHbBh7LrjRpr8RVRNZRvVLFWpluKVCriTyJI4XGcLdEq76nylgZlSlhNK4QZCoiE3dN7x67VtWVfsCgyHOdJUkpqQuUUJEsSPoZnWWljI2KHrL77nGfz11ZmfMwEY_-euYxu7Gh-gm7blCO6adoFC_lM0vCbxzuuHM |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+of+Solifenacin+on+Overactive+Bladder+Symptoms%2C+Symptom+Bother%2C+and+Other+Patient-Reported+Outcomes+in+Subjects+With+or+Without+Incontinence%3A+A+Post+Hoc+Analysis+of+Data+From+VIBRANT&rft.jtitle=Female+pelvic+medicine+%26+reconstructive+surgery&rft.au=Vardy%2C+Michael+D&rft.au=Mitcheson%2C+H+David&rft.au=Samuels%2C+Terri-Ann&rft.au=Forero-Schwanhaeuser%2C+Sergio&rft.date=2011-01-01&rft.issn=2151-8378&rft.eissn=2154-4212&rft.volume=17&rft.issue=1&rft.spage=24&rft_id=info:doi/10.1097%2FSPV.0b013e3182042929&rft_id=info%3Apmid%2F22453669&rft_id=info%3Apmid%2F22453669&rft.externalDocID=22453669 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2151-8378&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2151-8378&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2151-8378&client=summon |