Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

• Published in: Experimental & molecular medicine Vol. 38; no. 6; pp. 694 - 702
• Main Authors: Park, Byung Lae, Kim, Yoon Jun, Cheong, Hyun Sub, Kim, Lyoung Hyo, Choi, Yoo Hyun, Lee, Hyo-Suk, Shin, Hyoung Doo
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 31.12.2006
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - virology; Chemokine CCL2 - genetics; Female; Haplotypes - genetics; Hepatitis B; Hepatitis B - complications; Hepatitis B - genetics; Hepatitis B - therapy; Hepatitis B - virology; Hepatitis B virus; Hepatitis B virus - physiology; Hepatitis C virus; Humans; Male; Middle Aged; Polymorphism, Genetic - genetics; Promoter Regions, Genetic - genetics
• ISSN: 2092-6413; 1226-3613; 2092-6413
• DOI: 10.1038/emm.2006.82

Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including angiotensinogen (AGT), cadherin 1 (CDH1), cyclooxygenase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n=1,095) recruited from the Korean population. In addition, three polymorphisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis controlling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A allele (MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was significantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P=0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.