The Chemical Synthesis of Relaxin and Related Peptides

• Published in: Annals of the New York Academy of Sciences Vol. 1160; no. 1; pp. 11 - 15
• Main Authors: Wade, John D., Lin, Feng, Hossain, M. Akhter, Shabanpoor, Fazel, Zhang, Suode, Tregear, Geoffrey W.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.04.2009
• Subjects: Animals; chemical synthesis; Humans; insulin-like peptide; Peptides - chemical synthesis; Peptides - chemistry; regioselective disulfide bond formation; relaxin; Relaxin - analogs & derivatives; Relaxin - chemical synthesis; Relaxin - chemistry; solid-phase peptide synthesis

Successful methods for the chemical assembly of insulin‐like peptides allow the detailed study of their structure and function relationships. However, the two‐chain, three‐disulfide bond structure of this family of peptides, which includes relaxin, has long represented a significant challenge with r...