Hypercalcemia as the Initial Presentation of Acute T-cell Leukemia/Lymphoma

Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy that generally presents with widespread involvement of lymph nodes, peripheral blood, and/or skin. It is an uncommon malignancy linked to the human T-lymphotropic virus 1 (HTLV-1). Herein, we present a case of ATLL that was diagnosed after...

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Published inCurēus (Palo Alto, CA) Vol. 14; no. 3; p. e23705
Main Author Ramachandran, Vignesh
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 31.03.2022
Cureus
Subjects
Abdomen
Blood cancer
Blood tests
Case reports
Family/General Practice
Health care access
Hypercalcemia
Infections
Internal Medicine
Laboratories
Leukemia
Lymphoma
Metabolism
Pathology
Patients
Peptides
Primary care
New York
United States > US
hypercalcemia
adult t-cell leukemia/lymphoma
clinical pathology
general internal medicine
inpatient care
pathophysiology
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Summary:Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy that generally presents with widespread involvement of lymph nodes, peripheral blood, and/or skin. It is an uncommon malignancy linked to the human T-lymphotropic virus 1 (HTLV-1). Herein, we present a case of ATLL that was diagnosed after a patient presented to our hospital with nonspecific symptoms of fatigue and weakness and was subsequently found to have hypercalcemia secondary to his blood malignancy. We engage in a discussion of the etiology, epidemiology, and management of patients with this rare malignancy as well as the mechanisms that result in hypercalcemia.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.23705