Gene Expression Profiles Normalized in Psoriatic Skin by Treatment with Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody - Russell, Chris B; Rand, Hugh; Bigler, Jeannette; Kerkof, Keith; Timour, Martin; Bautista, Edgar; Krueger, James G; Salinger, David H; Welcher, Andrew A; Martin, David A (The Journal of immunology (1950), 2014)
Keywords: Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Cluster Analysis; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation - drug effects; Humans; Interferon-gamma - genetics; Interferon-gamma - metabolism; Interleukin-17 - genetics; Interleukin-17 - metabolism; Keratinocytes - drug effects; Keratinocytes - metabolism; Psoriasis - drug therapy; Psoriasis - genetics; Receptors, Interleukin-17 - antagonists & inhibitors; Skin - drug effects; Skin - metabolism; Skin - pathology; T-Lymphocytes - drug effects; T-Lymphocytes - metabolism; Transcriptome