Anti-CEA tagged iron nanoparticles for targeting triple-negative breast cancer

• Published in: Biomedical materials (Bristol) Vol. 16; no. 3; p. 35017
• Main Authors: Correa, Thais S, Bocca, Anamélia L, Figueiredo, Florêncio, Lima, Emilia C O, Almeida Santos, Maria De Fatima M, Lacava, Zulmira G M, Campos-da-Paz, Mariana
• Format: Journal Article
• Language: English
• Published: England 01.05.2021
• Subjects: Animals; Carcinoembryonic Antigen - therapeutic use; Cell Line, Tumor; Humans; Iron; Mice; Nanoparticles - chemistry; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; 4T1 orthotopic tumor model; targeting; carcinoembryonic antigen; magnetic nanoparticles

Systemic therapy is generally required for breast cancer. However, treatment toxicity and side effects are a concern, especially for triple-negative breast cancer (TNBC), a subtype that usually develops resistance to chemotherapy. To overcome this issue, new nanoformulations capable of targeting can...