LC-ESI-MS Determination of Roxithromycin in Tissues of Beagle Dogs after Multiple Dosing of Roxithromycin Sustained Release Tablets

• Published in: Chromatographia Vol. 66; no. 7-8; pp. 475 - 480
• Main Authors: Zha, Weibin, Sun, Jianguo, Wang, Guangji, Ren, Hongcan, Hu, Xiaoling, Huang, Qing, A, Jiye
• Format: Journal Article
• Language: English
• Published: Oxford Wiesbaden : Vieweg Verlag 01.10.2007; Springer
• Subjects: Analysis; Beagle dogs; Biological and medical sciences; General pharmacology; LC-ESI-MS; liquid chromatography; Medical sciences; Pharmacology. Drug treatments; roxithromycin; tissue distribution; Chemical analysis; HPLC chromatography; Roxithromycin; Solvent extraction; Electrospray; Tissue; Sample preparation; Tablet; Dog; Quantitative analysis; Validation; Fissipedia; Carnivora; Liquid liquid extraction; Controlled release form; Coupled method; Oral administration; Macrolide; Column liquid chromatography LC-ESI-MS Roxithromycin Beagle dogs Tissue distribution; Vertebrata; Antibiotic; Mammalia; Animal; Distribution; Antibacterial agent; Pharmacokinetics; Mass spectrometry

Roxithromycin, often regarded as an 'advanced-generation' macrolide, is widely used throughout the world. To exactly evaluate the efficacy of roxithromycin sustained release tablets on tissue pharmacokinetic and pharmacodynamic parameters, we developed a reliable LC-ESI-MS method for the d...