HER-2/neu receptor in prostate cancer development and progression to androgen independence

• Published in: Tumori Vol. 90; no. 2; p. 163
• Main Authors: Di Lorenzo, Giuseppe, Autorino, Riccardo, De Laurentiis, Michele, Cindolo, Luca, D'Armiento, Massimo, Bianco, Angelo Raffaele, De Placido, Sabino
• Format: Journal Article
• Language: English
• Published: United States 01.03.2004
• Subjects: Androgens - metabolism; Antineoplastic Agents - pharmacology; Biomarkers, Tumor - metabolism; Disease Progression; Gene Expression Regulation, Neoplastic - drug effects; Humans; Immunohistochemistry; Male; Neoplasms, Hormone-Dependent - metabolism; Prostate - metabolism; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - metabolism; Receptor Cross-Talk - drug effects; Receptor, Epidermal Growth Factor - drug effects; Receptor, Epidermal Growth Factor - metabolism; Receptor, ErbB-2 - drug effects; Receptor, ErbB-2 - metabolism; Signal Transduction

Development of prostate cancer and progression to androgen-independent disease is correlated with increased expression of growth factors and receptors capable of establishing autocrine and/or paracrine growth-stimulatory loops. A thorough review was made of the current literature and recent abstract...