Immunotherapy Targeting CCR8+ Regulatory T Cells Induces Antitumor Effects via Dramatic Changes to the Intratumor CD8+ T Cell Profile

• Published in: The Journal of immunology (1950) Vol. 211; no. 4; pp. 673 - 682
• Main Authors: Ueyama, Azumi, Nogami, Wataru, Nashiki, Kunitaka, Haruna, Miya, Miwa, Hiroto, Hagiwara, Masaki, Nagira, Morio, Wada, Hisashi, Nagira, Yoji
• Format: Journal Article
• Language: English
• Published: United States 15.08.2023
• Subjects: Animals; CD8-Positive T-Lymphocytes; Humans; Immunotherapy - methods; Mice; Neoplasms - pathology; T-Lymphocytes, Regulatory; Tumor Microenvironment

Regulatory T cells (Tregs) contribute to the formation of a tumor-immunosuppressive microenvironment. CCR8 is reportedly selectively expressed in tumor Tregs, and an anti-CCR8 Ab can exert potent antitumor effects by eliminating intratumor Tregs in murine tumor models. In this study, we analyzed cha...