Effect of insulin treatment on tissue size of the genitourinary tract in BB rats with spontaneously developed and streptozotocin-induced diabetes

• Published in: Naunyn-Schmiedeberg's archives of pharmacology Vol. 372; no. 3; pp. 251 - 255
• Main Authors: Yono, Makoto, Pouresmail, Mehdi, Takahashi, Wataru, Flanagan, Joan F, Weiss, Robert M, Latifpour, Jamshid
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2005
• Subjects: Animals; Blood Glucose - drug effects; Body Weight - drug effects; Diabetes Mellitus, Experimental - drug therapy; Disease Models, Animal; Hyperglycemia - drug therapy; Hypoglycemic Agents - blood; Hypoglycemic Agents - therapeutic use; Insulin - blood; Insulin - therapeutic use; Male; Organ Size - drug effects; Rats; Rats, Inbred BB; Streptozocin; Urogenital System - drug effects

To examine the differences between spontaneous and streptozotocin (STZ)-induced diabetes, four parallel studies were performed; three studies of diabetes-prone BB (BBDP/Wor) rats maintained for 8, 16, and 32 weeks and one study of STZ-injected diabetes-resistant BB (BBDR/Wor) rats maintained for 32...