Applications and Utility of Three-Dimensional In Vitro Cell Culture for Therapeutics

The field of 3D cell culture and its applications is rooted in the understanding of cell biology, tissue engineering, tissue morphology, disease mechanisms, and drug action. For many years, traditional 2D cell culture systems have been widely used but have proven to be limited in their ability to ac...

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Bibliographic Details
Published inFuture pharmacology Vol. 3; no. 1; pp. 213 - 228
Main Authors Ajjarapu, Suchitra Maheswari, Tiwari, Apoorv, Kumar, Sundip
Format Journal Article
LanguageEnglish
Published MDPI AG 01.03.2023
Subjects
cell
disease
drug
molecules
tissue
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Summary:The field of 3D cell culture and its applications is rooted in the understanding of cell biology, tissue engineering, tissue morphology, disease mechanisms, and drug action. For many years, traditional 2D cell culture systems have been widely used but have proven to be limited in their ability to accurately replicate the complex microenvironment of tissues. This often results in issues with cell proliferation, aggregation, and differentiation. 3D cell culture systems have emerged as a solution to this problem and have demonstrated a more accurate simulation of in vivo physiology. This has had a major impact on drug discovery and includes the use of spheroids, organoids, scaffolds, hydrogels, and organs. This review has addressed fundamental questions and exploited utility in 3D in vitro mode of cell culture in view of therapeutics.
ISSN:2673-9879
2673-9879
DOI:10.3390/futurepharmacol3010015