Quantifying relative virulence: when μ max fails and AUC alone just is not enough

• Published in: Journal of general virology Vol. 102; no. 1
• Main Authors: Ceballos, Ruben Michael, Stacy, Carson Len
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 2021
• Subjects: Archaea - growth & development; Archaea - virology; Area Under Curve; Fuselloviridae - growth & development; Fuselloviridae - pathogenicity; Host-Pathogen Interactions; Models, Biological; Short Communication; Virology - methods; Virulence; Virus Replication; Viruses - growth & development; Viruses - pathogenicity; Gompertz model; relative virulence; non-lytic viruses; virus–host dynamicsx; Sulfolobus spindle-shaped virus; growth curve analysis

A challenge in virology is quantifying relative virulence ( V R ) between two (or more) viruses that exhibit different replication dynamics in a given susceptible host. Host growth curve analysis is often used to mathematically characterize virus–host interactions and to quantify the magnitude of de...