Short-term prognosis of childhood hepatoblastoma in relation to ERCC1 C118T single nucleotide polymorphism and VEGF expression

• Published in: Polish journal of pathology Vol. 70; no. 4; pp. 304 - 310
• Main Authors: Wen, Yuan, Zhang, Weiling, Zhang, Yi, Hu, Huimin, Li, Jing, Huang, Dongsheng
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 2019
• Subjects: Angiogenesis; Antineoplastic Combined Chemotherapy Protocols; Cancer therapies; Chemotherapy; Child; Deoxyribonucleic acid; DNA; DNA Repair; DNA-Binding Proteins - genetics; Drugs; Endonucleases - genetics; ercc1 gene; Gene expression; Genotype; hepatoblastoma; Hepatoblastoma - diagnosis; Hepatoblastoma - genetics; Humans; Liver Neoplasms - diagnosis; Liver Neoplasms - genetics; Medical prognosis; Mutation; Pediatrics; platinum drugs; Polymorphism, Single Nucleotide; Prognosis; single nucleotide polymorphism; Software; Statistical analysis; Survival analysis; Survival Rate; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; vegf; United States > US; China; hepatoblastoma; ERCC1 gene; single nucleotide polymorphism; prognosis; VEGF; platinum drugs
• DOI: 10.5114/pjp.2019.93134
• ISSN: 1233-9687

To evaluate the short-term prognosis of pediatric hepatoblastoma (HB) in relation to excision repair cross-complementation gene 1 (ERCC1) C118T single nucleotide polymorphism (SNP) and VEGF expression. ERCC1 C118T SNP and VEGF expression were detected and investigated in 31 children with HB undergoing platinum-based chemotherapy, to analyze their relationship with short-term pediatric HB prognosis. CC (38.7%; 12/31), CT (35.5%; 11/31), and TT (25.8%; 8/31) ERCC1 C118T mutation types were identified. The Kaplan-Meier survival curve analysis showed that the CC group had a better short-term prognosis than the CT + TT group (p = 0.010). VEGF was overexpressed in 14 cases (45.2%) and underexpressed in 17 cases (54.8%). The Kaplan-Meier survival curve analysis showed that the high VEGF expression group showed poorer short-term prognosis than the lower VEGF expression group (p = 0.004). In this study, ERCC1 C118T SNP in children with HB was mainly found to be mutant type CT + TT. Compared to wild type CC, children with the mutant type CT + TT exhibited better treatment efficacy and remission with platinum-based chemotherapy as well as better survival rates. Moreover, the short-term prognosis of children with low VEGF expression was better than in those with high expression.