The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects

• Published in: Drug metabolism and disposition Vol. 51; no. 5; pp. 599 - 609
• Main Authors: Amore, Benny M., Cramer, Clay, MacDougall, Diane, Emery, Maurice G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2023
• Subjects: Administration, Oral; Adult; ATP Citrate (pro-S)-Lyase; Feces; Glucuronides; Humans; Male; Research Subjects; UGT; AE; LDL-C; ACSVL1; CLr; HLM; AUCinf; IS; MS/MS; AUC; Vz/F; LDL; t1/2; UDPGA; LC; Tmax; AUC0-last; m/z; r.t; PK; LSC; HPLC; CL/F

The disposition and metabolism of bempedoic acid, a selective inhibitor of ATP citrate lyase, were examined in healthy male subjects. After a single administration of [14C] bempedoic acid (240 mg, 113 μ Ci) oral solution, mean concentrations of total radioactivity in plasma as a function of time ind...