Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study

• Published in: Tuberkulëz i bolezni lëgkikh Vol. 98; no. 10; pp. 33 - 40
• Main Authors: Vizel, A. A., Culver, D. A., Vizel, I. Yu, Shakirova, G. R., Bakunina, E. A.
• Format: Journal Article
• Language: Russian
• Published: New Terra Publishing House 14.11.2020
• Subjects: alpha-tocopherol; comparison; follow-up; sarcoidosis; treatment
• DOI: 10.21292/2075-1230-2020-98-10-33-40
• ISSN: 2075-1230

The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46). Conclusion. The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment.