Glomerulopathy in spontaneously diabetic rat: impact of glycemic control
The spontaneously diabetic BioBreeding/Worcester (BB/W) rat was used to examine the role of glycemic control in the pathogenesis of diabetic glomerulopathy and proteinuria. Nondiabetic BB/W rats (group 1) were compared with moderately (group 2) and severely (group 3) hyperglycemic diabetic animals o...
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Published in | Diabetes (New York, N.Y.) Vol. 36; no. 8; pp. 944 - 951 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Alexandria, VA
American Diabetes Association
01.08.1987
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Subjects | |
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Abstract | The spontaneously diabetic BioBreeding/Worcester (BB/W) rat was used to examine the role of glycemic control in the pathogenesis of diabetic glomerulopathy and proteinuria. Nondiabetic BB/W rats (group 1) were compared with moderately (group 2) and severely (group 3) hyperglycemic diabetic animals of similar age. Urinary protein excretion and morphometric measurements of glomerular basement membrane (GBM) width and mesangial area were performed after 4, 8, and 12 mo of study. At 4 mo, urinary protein excretion both in group 2 (9.3 +/- 0.7 mg/24 h) and group 3 (24.8 +/- 1.98 mg/24 h) exceeded that in group 1 (5.4 +/- 0.6 mg/24 h; P less than .05). Moreover, proteinuria in group 3 was significantly greater than in group 2 (P less than .05). In addition, proteinuria increased in group 3 animals between 4 and 12 mo of study but did not advance in groups 1 or 2. GBM width in both diabetic groups (168.8 +/- 2.4 and 165.7 +/- 2.2 nm, groups 2 and 3, respectively) exceeded that in group 1 (148.3 +/- 3.8 nm; P less than .01) by 4 mo. At 12 mo, severely hyperglycemic group 3 animals had significantly greater GBM thickening than group 2. GBM width increased in all three groups over the course of study, but the rate of growth did not differ between groups 1 and 2. However, the rate of growth in group 3 was greater than in either group 1 or group 2. Urinary protein excretion correlated significantly with GBM width in diabetic rats. |
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AbstractList | The spontaneously diabetic BioBreeding/Worcester (BB/W) rat was used to examine the role of glycemic control in the pathogenesis of diabetic glomerulopathy and proteinuria. Nondiabetic BB/W rats (group 1) were compared with moderately (group 2) and severely (group 3) hyperglycemic diabetic animals of similar age. Urinary protein excretion and morphometric measurements of glomerular basement membrane (GBM) width and mesangial area were performed after 4, 8, and 12 mo of study. At 4 mo, urinary protein excretion both in group 2 (9.3 +/- 0.7 mg/24 h) and group 3 (24.8 +/- 1.98 mg/24 h) exceeded that in group 1 (5.4 +/- 0.6 mg/24 h; P less than .05). Moreover, proteinuria in group 3 was significantly greater than in group 2 (P less than .05). In addition, proteinuria increased in group 3 animals between 4 and 12 mo of study but did not advance in groups 1 or 2. GBM width in both diabetic groups (168.8 +/- 2.4 and 165.7 +/- 2.2 nm, groups 2 and 3, respectively) exceeded that in group 1 (148.3 +/- 3.8 nm; P less than .01) by 4 mo. At 12 mo, severely hyperglycemic group 3 animals had significantly greater GBM thickening than group 2. GBM width increased in all three groups over the course of study, but the rate of growth did not differ between groups 1 and 2. However, the rate of growth in group 3 was greater than in either group 1 or group 2. Urinary protein excretion correlated significantly with GBM width in diabetic rats. The spontaneously diabetic BioBreeding/Worcester (BB/W) rat was used to examine the role of glycemie control in the pathogenesis of diabetic glomerulopathy and proteinuria. Nondiabetic BB/W rats (group 1) were compared with moderately (group 2) and severely (group 3) hyperglycemie diabetic animals of similar age. Urinary protein excretion and morphometric measurements of glomerular basement membrane (GBM) width and mesangial area were performed after 4, 8, and 12 mo of study. At 4 mo, urinary protein excretion both in group 2 (9.3 ± 0.7 mg/24 h) and group 3 (24.8 ± 1.98 mg/24 h) exceeded that in group 1 (5.4 ± 0.6 mg/24 h; P < .05). Moreover, proteinuria in group 3 was significantly greater than in group 2 (P < .05). In addition, proteinuria increased in group 3 animals between 4 and 12 mo of study but did not advance in groups 1 or 2. GBM width in both diabetic groups (168.8 ± 2.4 and 165.7 ± 2.2 nm, groups 2 and 3, respectively) exceeded that in group 1 (148.3 ± 3.8 nm; P < .01) by 4 mo. At 12 mo, severely hyperglycemie group 3 animals had significantly greater GBM thickening than group 2. GBM width increased in all three groups over the course of study, but the rate of growth did not differ between groups 1 and 2. However, the rate of growth in group 3 was greater than in either group 1 or group 2. Urinary protein excretion correlated significantly with GBM width in diabetic rats. No differences in proportional mesangial area or the proportional area made up of mesangial matrix or cytoplasm could be found among the three groups. In the spontaneously diabetic BB/W rat, poor glycemie control contributes to both proteinuria and GBM widening but apparently does not cause mesangial expansion. Proteinuria and GBM widening may either be interdependent or related to a common third factor in the diabetic milieu. |
Author | COHEN, A. J GUBERSKI, D. L LIKE, A. A MCGILL, P. D ROSSETTI, R. G |
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Keywords | Endocrinopathy Glomerulonephritis Rat Diabetes mellitus Spontaneous Rodentia Glucose tolerance test Glucose Metabolism Renal glomerulus Vertebrata Mammalia Complication |
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Snippet | The spontaneously diabetic BioBreeding/Worcester (BB/W) rat was used to examine the role of glycemic control in the pathogenesis of diabetic glomerulopathy and... The spontaneously diabetic BioBreeding/Worcester (BB/W) rat was used to examine the role of glycemie control in the pathogenesis of diabetic glomerulopathy and... |
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SubjectTerms | Animals Basement Membrane - pathology Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - pathology Diabetes. Impaired glucose tolerance Diabetic Nephropathies - blood Diabetic Nephropathies - etiology Diabetic Nephropathies - pathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Glomerular Mesangium - pathology Kidney Glomerulus - pathology Medical sciences Proteinuria - etiology Rats Rats, Inbred BB |
Title | Glomerulopathy in spontaneously diabetic rat: impact of glycemic control |
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