Application of bacterial therapeutic vaccine Immunovac-VP4 in the treatment of pollinosis

• Published in: Terapevtic̆eskii arhiv Vol. 90; no. 3; pp. 16 - 20
• Main Authors: Kostinov, M P, Poddubikova, A M, Magarshak, O O, Poddubikov, A V
• Format: Journal Article
• Language: English; Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 19.04.2018
• Subjects: Adult; allergen-specific immunotherapy; Allergens; bacterial vaccines; Bacterial Vaccines - therapeutic use; Child; desensitization; Desensitization, Immunologic; Humans; immunovac-vp4; pamps; pollinosis; Rhinitis, Allergic, Seasonal - immunology; Rhinitis, Allergic, Seasonal - therapy; Treatment Outcome; Immunovac-VP4; PAMPs; bacterial vaccines; desensitization; pollinosis; allergen-specific immunotherapy
• ISSN: 0040-3660; 2309-5342
• DOI: 10.26442/terarkh201890316-20

The aim of the study was to study the effectiveness of the complex use of bacterial therapeutic vaccine Immunovac-VP4 and allergen-specific immune therapy (ASIT) in pollinosis in children and adults. Bacterial therapeutic vaccine Immunovac-VP4 was used annually, nasal and oral administration in patients before the course of ASIT standardized aqueous-salt solutions of allergens. The therapeutic application of bacterial vaccines, Immunoac-ВП4 before the course ASIT has helped to reduce the frequency of acute respiratory infections in 8,5 times in comparison with the control group. Clinical efficacy of complex treatment according to the results of the survey of patients in 7 years after the start of therapy was 90%. There was a significant decrease In IgG4 to causally significant allergens, General immnunoglobulin E (IgE) and a tendency to decrease IgE. The use of bacterial therapeutic vaccine Immunovac-VP4, which is a natural ligand of toll-like receptors in combination with ASIT, seems to be an effective and promising direction in the treatment of allergic diseases.