Mechanism of NLRX1 mediating JNK apoptosis pathway to participate in functional impairment of cochlear hair cells in mice with senile deafness

• Published in: Cellular and Molecular Biology Vol. 68; no. 10; pp. 111 - 116
• Main Authors: Yang, Xiao, Ju, Ruihua, Wang, Yaning, Gu, Lintao
• Format: Journal Article
• Language: English
• Published: France 30.09.2022
• Subjects: Animals; Apoptosis - genetics; bcl-2-Associated X Protein - metabolism; Caspase 3 - metabolism; Cochlea - metabolism; Deafness - metabolism; Hair Cells, Auditory - metabolism; Hearing Loss, Sensorineural - genetics; Hearing Loss, Sensorineural - metabolism; MAP Kinase Kinase 4 - metabolism; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitochondrial Proteins - metabolism; Presbycusis - genetics; Presbycusis - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism

To explore the mechanism of cochlear hair cell damage and study the prevention and treatment of sensorineural hearing loss, the effect of NLRX1 gene expression on the functional damage of cochlear hair cells in presbycusis was comprehensively analyzed. In the in vivo detection, C57BL/6 mice of diffe...