NMDA receptor-mediated arachidonic acid release in neurons: role in signal transduction and pathological aspects

• Published in: Advances in experimental medicine and biology Vol. 318; p. 73
• Main Authors: Lazarewicz, J W, Salinska, E, Wroblewski, J T
• Format: Journal Article
• Language: English
• Published: United States 1992
• Subjects: Animals; Arachidonic Acid - metabolism; Brain Ischemia - physiopathology; Cerebellum - metabolism; Gerbillinae; Hippocampus - metabolism; In Vitro Techniques; Neurons - metabolism; Phospholipases A - metabolism; Phospholipases A2; Rats; Receptors, N-Methyl-D-Aspartate - physiology; Signal Transduction - physiology

The N-methyl-D-aspartate (NMDA)-sensitive subtype of glutamate receptor, which gates Ca(2+)-permeable ion channels, is known for its role in learning and memory formation, in the induction of long-term potentiation, and also in seizure activity and neurotoxicity. In primary cultures of cerebellar ne...