Novel Selective Cardiac Myosin-Targeted Inhibitors Alleviate Myocardial Ischaemia–Reperfusion Injury

• Published in: Cardiovascular drugs and therapy
• Main Authors: Yusof, Nur Liyana Mohammed, Yellon, Derek M., Davidson, Sean M.
• Format: Journal Article
• Language: English
• Published: United States 04.01.2025
• Subjects: Ischaemia; Myocardial infarction; Aficamten; Hypercontracture; Reperfusion; Mavacamten

Reperfusion of the ischaemic heart is essential to limit myocardial infarction. However, reperfusion can cause cardiomyocyte hypercontracture. Recently, cardiac myosin-targeted inhibitors (CMIs), such as Mavacamten (MYK-461) and Aficamten (CK-274), have been developed to treat patients with cardiac...