Engineered multi-domain lipid nanoparticles for targeted delivery

• Published in: Chemical Society reviews Vol. 54; no. 12; pp. 5961 - 5994
• Main Authors: Liu, Zhaoyu, Chen, Jingxun, Xu, Mingkun, Ho, Sherwin, Wei, Yuanyuan, Ho, Ho-Pui, Yong, Ken-Tye
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 16.06.2025
• Subjects: Animals; Artificial intelligence; Complexity; Design optimization; Drug Delivery Systems; Humans; Lipids; Lipids - chemistry; Molecular dynamics; Molecular Dynamics Simulation; Nanoparticles; Nanoparticles - chemistry

Engineered lipid nanoparticles (LNPs) represent a breakthrough in targeted drug delivery, enabling precise spatiotemporal control essential to treat complex diseases such as cancer and genetic disorders. However, the complexity of the delivery process-spanning diverse targeting strategies and biolog...