Voluntary exercise counteracts Aβ25-35-induced memory impairment in mice

• Published in: Behavioural brain research Vol. 256; pp. 618 - 625
• Main Authors: Wang, Qin, Xu, Zhiqiang, Tang, Jinrong, Sun, Jianguo, Gao, Junying, Wu, Ting, Xiao, Ming
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.11.2013; Elsevier
• Subjects: Adult and adolescent clinical studies; Alzheimer's disease; Amyloid beta-Peptides - pharmacology; Amyloid peptide; Angiogenesis; Animals; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Hippocampus - drug effects; Hippocampus - physiopathology; Male; Maze Learning - drug effects; Maze Learning - physiology; Medical sciences; Memory - drug effects; Memory - physiology; Memory Disorders - chemically induced; Memory Disorders - therapy; Mice; Neurology; Neurotoxicity; Organic mental disorders. Neuropsychology; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - physiology; Peptide Fragments - pharmacology; Physical Conditioning, Animal - physiology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Voluntary exercise; Oxidative stress; Angiogenesis; Neurotoxicity; Voluntary exercise; Alzheimer's disease; Amyloid peptide; Physical exercise; Memory disorder; Nervous system diseases; Cognitive disorder; Alzheimer disease; Rodentia; Cerebral disorder; Vertebrata; Mammalia; Mouse; Animal; Central nervous system disease; Degenerative disease; Amyloid

•Voluntary exercise mitigates Aβ25-35 induced memory deficits in mice.•Voluntary exercise decreases Aβ25-35 induced neurodegeneration in the hippocampus.•Voluntary exercise decreases Aβ25-35 induced oxidative stress in the hippocampus.•Voluntary exercise induces hippocampal angiogenesis in Aβ25-35 t...