Effects of sildenafil on the viability of random skin flaps

• Published in: Acta cirurgica brasileira Vol. 26; no. 4; pp. 314 - 319
• Main Authors: Barral, Sumara Marques, Araujo, Ivana Duval, Vidigal, Paula Vieira Teixeira, Mayrink, Cláudio Alvarenga Campos, Araujo, Adriana Duval, Costa, Paulo Roberto da
• Format: Journal Article
• Language: English
• Published: Brazil 01.08.2011
• Subjects: Animals; Biopsy; Dermatologic Surgical Procedures; Female; Necrosis - pathology; Phosphodiesterase 5 Inhibitors - pharmacology; Piperazines - pharmacology; Purines - pharmacology; Rats; Rats, Wistar; Sildenafil Citrate; Skin - drug effects; Skin - pathology; Sulfones - pharmacology; Surgical Flaps - pathology; Tissue Survival - drug effects; Wound Healing

To assess the viability of McFarlane skin flaps in rats with administration of sildenafil. Twenty Wistar rats were distributed into two groups: Control (dorsal skin flap, subdermal application of saline solution at 0.9%) and Study (dorsal skin flap, subdermal application of sildenafil). Seven days a...