Controlled diuretic monotherapy in hypertensive patients: Efficiency and metabolic safety

• Published in: Terapevtic̆eskii arhiv Vol. 88; no. 9; pp. 59 - 64
• Main Authors: Semenkin, A A, Zhivilova, L A, Nechaeva, G I, Chindareva, O I, Loginova, E N, Pritykina, T V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 01.01.2016
• Subjects: Adult; antihypertensive efficiency; blood glucose; Blood Glucose - analysis; blood lipids; Blood Pressure - drug effects; Diuretics - administration & dosage; Diuretics - adverse effects; Diuretics - pharmacokinetics; Drug Monitoring - methods; Drug-Related Side Effects and Adverse Reactions - etiology; Drug-Related Side Effects and Adverse Reactions - metabolism; Drug-Related Side Effects and Adverse Reactions - prevention & control; Essential Hypertension; Female; Humans; hydrochlorothiazide; Hydrochlorothiazide - administration & dosage; Hydrochlorothiazide - adverse effects; Hydrochlorothiazide - pharmacokinetics; hypertension; Hypertension - drug therapy; Hypertension - metabolism; indapamide; Indapamide - administration & dosage; Indapamide - adverse effects; Indapamide - pharmacokinetics; Male; Middle Aged; monotherapy; Patient Acuity; Treatment Outcome; Triglycerides - blood

To evaluate the antihypertensive efficiency and metabolic effects of controlled monotherapy with hydrochlorothiazide (HCT) and indapamide retard (IR) in hypertensive patients. The study included 50 patients with Stage II essential hypertension, grades 1-3 blood pressure (BP) elevation, who received...