Therapeutic leukapheresis in a patient with prolymphocytic transformation of B-cell chronic lymphocytic leukemia

A 64-year old woman with chronic lymphocytic leukemia (CLL) developed a prolymphocytic transformation with severe anemia, thrombocytopenia and deterioration of the general clinical condition. Neither treatment with chlorambucil and prednisolone, nor a combination chemotherapy (cyclophosphamide, vinc...

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Bibliographic Details
Published inInternational journal of artificial organs Vol. 7; no. 3; p. 139
Main Authors Steenssens, L, Van Camp, B
Format Journal Article
LanguageEnglish
Published United States 01.05.1984
Subjects
B-Lymphocytes
Female
Humans
Leukapheresis
Leukemia, Lymphoid - blood
Leukemia, Lymphoid - pathology
Leukemia, Lymphoid - therapy
Leukocyte Count
Lymphocytes - pathology
Middle Aged
Spleen - pathology
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Summary:A 64-year old woman with chronic lymphocytic leukemia (CLL) developed a prolymphocytic transformation with severe anemia, thrombocytopenia and deterioration of the general clinical condition. Neither treatment with chlorambucil and prednisolone, nor a combination chemotherapy (cyclophosphamide, vincristine, prednisolone) were successful. Splenectomy was not considered as the bone marrow presented signs of dyserythropoiesis. Encouraged by the results of therapeutic leukapheresis in different forms of leukemia, it was decided to start such therapy in our patient. During a seven-month period, thirty weekly aphereses were performed. The white blood cell count did not decrease, but the clinical condition of the patient improved dramatically.
ISSN:0391-3988
1724-6040
DOI:10.1177/039139888400700308