Chitosan nanoparticles laden contact lenses for enzyme-triggered controlled delivery of timolol maleate: A promising strategy for managing glaucoma

• Published in: Drug delivery and translational research Vol. 14; no. 11; pp. 3212 - 3224
• Main Authors: Maulvi, Furqan A., Patel, Ashmi R., Shetty, Kiran H., Desai, Ditixa T., Shah, Dinesh O., Willcox, Mark D. P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2024
• Subjects: Administration, Ophthalmic; Animals; Biomedical and Life Sciences; Biomedicine; Chitosan - administration & dosage; Chitosan - chemistry; Contact Lenses; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - chemistry; Drug Delivery Systems; Drug Liberation; Glaucoma - drug therapy; Intraocular Pressure - drug effects; Muramidase - administration & dosage; Muramidase - chemistry; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Original Article; Pharmaceutical Sciences/Technology; Rabbits; Tears; Timolol - administration & dosage; Timolol - chemistry; Timolol - pharmacokinetics; Glaucoma; Controlled drug delivery; Timolol maleate; Chitosan nanoparticles; Contact lens

To improve drug bioavailability, eye drops can be replaced by drug-eluting contact lenses. However, issues of drug leaching from lenses during manufacture and storage, and sterilization, currently limit their commercial application. To address the issues, stimuli-(lysozyme)-sensitive chitosan nanopa...