Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-κB pathway

• Published in: International Journal of Obesity Vol. 33; no. 4; pp. 465 - 472
• Main Authors: Lee, W-J, Wu, C-S, Lin, H, Lee, I-T, Wu, C-M, Tseng, J-J, Chou, M-M, Sheu, W H-H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2009; Nature Publishing Group
• Subjects: Cardiovascular diseases; Enzyme-linked immunosorbent assay; Epidemiology; Fat cells; Gene expression; Health aspects; Health Promotion and Disease Prevention; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Obesity; original-article; Public Health; Risk factors; Taiwan; adhesion; inflammation; endothelial cell; visfatin

Background: Visfatin is an adipokine that is highly expressed in visceral fat. Plasma levels of visfatin have been reported to be higher in subjects with obesity and/or type 2 diabetes mellitus. However, the role of visfatin in endothelial dysfunction has been largely unexplored. Objectives: We inve...