Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

• Published in: Nature biotechnology
• Main Authors: Eckert, Stephan, Berner, Nicola, Kramer, Karl, Schneider, Annika, Müller, Julian, Lechner, Severin, Brajkovic, Sarah, Sakhteman, Amirhossein, Graetz, Christian, Fackler, Jonas, Dudek, Michael, Pfaffl, Michael W, Knolle, Percy, Wilhelm, Stephanie, Kuster, Bernhard
• Format: Journal Article
• Language: English
• Published: United States 07.05.2024

Proteomics is making important contributions to drug discovery, from target deconvolution to mechanism of action (MoA) elucidation and the identification of biomarkers of drug response. Here we introduce decryptE, a proteome-wide approach that measures the full dose-response characteristics of drug-...