Development and utility of pirfenidone in the treatment of idiopathic pulmonary fibrosis: review of preclinical science and recent clinical trials

• Published in: Transplant research and risk management Vol. 3; p. 55
• Main Authors: Robert M Jackson, Robert, Orlando Gomez-Marin
• Format: Journal Article
• Language: English
• Published: Macclesfield Taylor & Francis Ltd 01.01.2011
• Subjects: Clinical trials; Kinases; Pulmonary fibrosis; Regulatory approval

Pirfenidone is a pyridine-derived, double-ringed molecule that has a number of biologic effects including anti-inflammatory and antifibrotic properties in rodent models of acute lung injury and fibrosis, in addition to scavenging reactive oxygen species. These effects are clinically relevant, becaus...