Metagenomics-Metabolomics Reveals the Alleviation of Indole-3-Ethanol on Radiation-Induced Enteritis in Mice

• Published in: Journal of microbiology and biotechnology Vol. 35; pp. e2502037 - 14
• Main Authors: Zhong, Hua, Song, Yipeng, Hu, Shanliang, Zhang, Chengxu, Li, Lili
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society for Microbiology and Biotechnology 18.07.2025; 한국미생물·생명공학회
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Colon - drug effects; Colon - pathology; Colon - radiation effects; Cytokines - metabolism; Enteritis - drug therapy; Enteritis - etiology; Enteritis - metabolism; Enteritis - microbiology; Enteritis - pathology; Gastrointestinal Microbiome - drug effects; Indoles - metabolism; Indoles - pharmacology; Interleukin-17 - metabolism; Male; Metabolomics - methods; Metagenomics - methods; Mice; Mice, Inbred C57BL; Research article; 생물학; Gut microbiota; radiotherapy; radiation enteritis; indole-3-ethanol; metabolites

Indole-3-ethanol (IEt), a small molecule metabolite from intestinal microbial tryptophan metabolism, has been established to have anti-inflammatory properties. However, its effect on radiation-induced enteritis has not been reported. Here, we aim to explore the effects and potential mechanisms of IE...