Mitochondrial signal transduction

• Published in: Cell metabolism Vol. 34; no. 11; pp. 1620 - 1653
• Main Authors: Picard, Martin, Shirihai, Orian S.
• Format: Journal Article
• Language: English
• Published: United States 01.11.2022
• Subjects: Cell Communication; Cell Nucleus - metabolism; Humans; Mitochondria - metabolism; Signal Transduction; metabokines; receptors; signal transduction; tissue-specific; health; evolution; stress responses; amplification; mito-nuclear signaling; mitochondrial networks; mitotypes; membrane potential; mitokines; steroid hormones; communication; energy

The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the...