Oxygen Uptake Rate Controlling Strategy Balanced with Oxygen Supply for Improving Coenzyme Q10 Production by Rhodobacter sphaeroides
The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased...
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| Published in | Biotechnology and bioprocess engineering Vol. 25; no. 3; pp. 459 - 469 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
The Korean Society for Biotechnology and Bioengineering
01.06.2020
Springer Nature B.V 한국생물공학회 |
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| Abstract | The effects of different oxygen uptake rates (OUR) on the physiological metabolism of
Rhodobacter sphaeroides
were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q
10
production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q
10
production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ
10
content was 25.9 mg/(g DCW)), and the yield of CoQ
10
to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ
10
production. |
|---|---|
| AbstractList | The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q10 production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q10 production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ10 content was 25.9 mg/(g DCW)), and the yield of CoQ10 to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ10 production. The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q 10 production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q 10 production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ 10 content was 25.9 mg/(g DCW)), and the yield of CoQ 10 to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ 10 production. The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q₁₀ production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q₁₀ production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ₁₀ content was 25.9 mg/(g DCW)), and the yield of CoQ₁₀ to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ₁₀ production. The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q10 production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q10 production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ10 content was 25.9 mg/(g DCW)), and the yield of CoQ10 to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ10 production. KCI Citation Count: 0 |
| Author | Zhang, Xingzi Zhuang, Yingping Zhang, Siliang Guo, Meijin Sui, Zhiwei Wang, Ping Wang, Ze-Jian |
| Author_xml | – sequence: 1 givenname: Ze-Jian surname: Wang fullname: Wang, Ze-Jian organization: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology; Shanghai Institute of Biomanufacturing Technology & Collaborative Innovation Center – sequence: 2 givenname: Xingzi surname: Zhang fullname: Zhang, Xingzi organization: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology; Shanghai Institute of Biomanufacturing Technology & Collaborative Innovation Center – sequence: 3 givenname: Ping surname: Wang fullname: Wang, Ping organization: National Institute of Metrology – sequence: 4 givenname: Zhiwei surname: Sui fullname: Sui, Zhiwei organization: National Institute of Metrology – sequence: 5 givenname: Meijin surname: Guo fullname: Guo, Meijin organization: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology; Shanghai Institute of Biomanufacturing Technology & Collaborative Innovation Center – sequence: 6 givenname: Siliang surname: Zhang fullname: Zhang, Siliang organization: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology; Shanghai Institute of Biomanufacturing Technology & Collaborative Innovation Center – sequence: 7 givenname: Yingping surname: Zhuang fullname: Zhuang, Yingping email: ypzhuang@ecust.edu.cn organization: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology; Shanghai Institute of Biomanufacturing Technology & Collaborative Innovation Center |
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| CitedBy_id | crossref_primary_10_1016_j_synbio_2021_09_011 crossref_primary_10_1186_s40643_024_00813_0 crossref_primary_10_1016_j_talanta_2022_123448 crossref_primary_10_1038_s41587_024_02267_3 crossref_primary_10_1016_j_biortech_2022_126678 |
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| Title | Oxygen Uptake Rate Controlling Strategy Balanced with Oxygen Supply for Improving Coenzyme Q10 Production by Rhodobacter sphaeroides |
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| ispartofPNX | Biotechnology and Bioprocess Engineering, 2020, 25(3), , pp.459-469 |
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