Transcriptomic profile of cumulus cells isolated from cumulus-oocyte complexes of prepubertal and adult sheep

Cumulus cells (CCs) are crucial during cumulus-oocyte complex (COC) growth, maturation and fertilization. Analysis of gene expression in CCs of in vitro matured oocytes help to identify non-invasive biomarkers of oocyte quality. This study compared transcriptomic profiles of CCs from matured oocytes...

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Published inTheriogenology Vol. 249; p. 117643
Main Authors Martino, Nicola Antonio, Temerario, Letizia, Parisi, Francesco, Mansi, Luigi, Bogliolo, Luisa, Mastrorocco, Antonella, Ariu, Federica, Podda, Andrea, Ciani, Elena, Manzari, Caterina, Picardi, Ernesto, Pesole, Graziano, Dell’Aquila, Maria Elena
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2026
Subjects
Adult sheep
Cumulus cells
Non-invasive biomarkers
Oocyte quality
Prepubertal lambs
Transcriptomic analysis
Non-invasive biomarkers
Prepubertal lambs
Transcriptomic analysis
Cumulus cells
Oocyte quality
Adult sheep
Online AccessGet full text
ISSN0093-691X
1879-3231
1879-3231
DOI10.1016/j.theriogenology.2025.117643

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Abstract Cumulus cells (CCs) are crucial during cumulus-oocyte complex (COC) growth, maturation and fertilization. Analysis of gene expression in CCs of in vitro matured oocytes help to identify non-invasive biomarkers of oocyte quality. This study compared transcriptomic profiles of CCs from matured oocytes of prepubertal (<6 months) and adult (3–5 years) sheep. COCs were individually in vitro cultured for in vitro maturation (IVM). After IVM, CCs were removed and only those isolated from matured oocytes were collected and analyzed. Samples (20–25 COCs/sample), 5 prepubertal vs 5 adults, were processed for RNA extraction, library preparation and deep transcriptome sequencing. Reads were aligned to the sheep reference genome (Oar_v3.1) using STAR (version 020201) and differentially expressed genes (DEGs) identified with DESeq2 (p < 0.05, |log2fc|>1.2). GO, KEGG, and gene network analyses elucidated gene functions, with validation via quantitative PCR. Results showed 1024 identified DEGs, 819 upregulated and 205 downregulated, in prepubertal sheep CCs. GO analysis associated with gene network enrichments allowed the identification of key genes of CC functionality related to donor age. In detail, DEGs were found to be involved in important CC functions such as: aromatase activity (CYP19A), growth factor-binding proteins (ERBB3, IGFBP2/3, PDGFRA, ITGAV), mitochondrial functions (SOD1, ATP5MF-ATP, ATPase H+/K+, MT-COX1/2/3, ND4L, NDUFS4, COX17) and regulation of cell-cell/cell-matrix interactions mediated by: integrins (ITGA6/L/V, ITGB4/8), collagen (COL1A/3A/5A) and cadherins (CDH4/6/13/17/18/23, DSG2). These findings enhance understanding of molecular mechanisms underlying oocyte development from early life to fertile age and offer potential non-invasive biomarkers of oocyte quality of adult cyclic subjects.
AbstractList Cumulus cells (CCs) are crucial during cumulus-oocyte complex (COC) growth, maturation and fertilization. Analysis of gene expression in CCs of in vitro matured oocytes help to identify non-invasive biomarkers of oocyte quality. This study compared transcriptomic profiles of CCs from matured oocytes of prepubertal (<6 months) and adult (3-5 years) sheep. COCs were individually in vitro cultured for in vitro maturation (IVM). After IVM, CCs were removed and only those isolated from matured oocytes were collected and analyzed. Samples (20-25 COCs/sample), 5 prepubertal vs 5 adults, were processed for RNA extraction, library preparation and deep transcriptome sequencing. Reads were aligned to the sheep reference genome (Oar_v3.1) using STAR (version 020201) and differentially expressed genes (DEGs) identified with DESeq2 (p < 0.05, |log2fc|>1.2). GO, KEGG, and gene network analyses elucidated gene functions, with validation via quantitative PCR. Results showed 1024 identified DEGs, 819 upregulated and 205 downregulated, in prepubertal sheep CCs. GO analysis associated with gene network enrichments allowed the identification of key genes of CC functionality related to donor age. In detail, DEGs were found to be involved in important CC functions such as: aromatase activity (CYP19A), growth factor-binding proteins (ERBB3, IGFBP2/3, PDGFRA, ITGAV), mitochondrial functions (SOD1, ATP5MF-ATP, ATPase H+/K+, MT-COX1/2/3, ND4L, NDUFS4, COX17) and regulation of cell-cell/cell-matrix interactions mediated by: integrins (ITGA6/L/V, ITGB4/8), collagen (COL1A/3A/5A) and cadherins (CDH4/6/13/17/18/23, DSG2). These findings enhance understanding of molecular mechanisms underlying oocyte development from early life to fertile age and offer potential non-invasive biomarkers of oocyte quality of adult cyclic subjects.Cumulus cells (CCs) are crucial during cumulus-oocyte complex (COC) growth, maturation and fertilization. Analysis of gene expression in CCs of in vitro matured oocytes help to identify non-invasive biomarkers of oocyte quality. This study compared transcriptomic profiles of CCs from matured oocytes of prepubertal (<6 months) and adult (3-5 years) sheep. COCs were individually in vitro cultured for in vitro maturation (IVM). After IVM, CCs were removed and only those isolated from matured oocytes were collected and analyzed. Samples (20-25 COCs/sample), 5 prepubertal vs 5 adults, were processed for RNA extraction, library preparation and deep transcriptome sequencing. Reads were aligned to the sheep reference genome (Oar_v3.1) using STAR (version 020201) and differentially expressed genes (DEGs) identified with DESeq2 (p < 0.05, |log2fc|>1.2). GO, KEGG, and gene network analyses elucidated gene functions, with validation via quantitative PCR. Results showed 1024 identified DEGs, 819 upregulated and 205 downregulated, in prepubertal sheep CCs. GO analysis associated with gene network enrichments allowed the identification of key genes of CC functionality related to donor age. In detail, DEGs were found to be involved in important CC functions such as: aromatase activity (CYP19A), growth factor-binding proteins (ERBB3, IGFBP2/3, PDGFRA, ITGAV), mitochondrial functions (SOD1, ATP5MF-ATP, ATPase H+/K+, MT-COX1/2/3, ND4L, NDUFS4, COX17) and regulation of cell-cell/cell-matrix interactions mediated by: integrins (ITGA6/L/V, ITGB4/8), collagen (COL1A/3A/5A) and cadherins (CDH4/6/13/17/18/23, DSG2). These findings enhance understanding of molecular mechanisms underlying oocyte development from early life to fertile age and offer potential non-invasive biomarkers of oocyte quality of adult cyclic subjects.
Cumulus cells (CCs) are crucial during cumulus-oocyte complex (COC) growth, maturation and fertilization. Analysis of gene expression in CCs of in vitro matured oocytes help to identify non-invasive biomarkers of oocyte quality. This study compared transcriptomic profiles of CCs from matured oocytes of prepubertal (<6 months) and adult (3-5 years) sheep. COCs were individually in vitro cultured for in vitro maturation (IVM). After IVM, CCs were removed and only those isolated from matured oocytes were collected and analyzed. Samples (20-25 COCs/sample), 5 prepubertal vs 5 adults, were processed for RNA extraction, library preparation and deep transcriptome sequencing. Reads were aligned to the sheep reference genome (Oar_v3.1) using STAR (version 020201) and differentially expressed genes (DEGs) identified with DESeq2 (p < 0.05, |log2fc|>1.2). GO, KEGG, and gene network analyses elucidated gene functions, with validation via quantitative PCR. Results showed 1024 identified DEGs, 819 upregulated and 205 downregulated, in prepubertal sheep CCs. GO analysis associated with gene network enrichments allowed the identification of key genes of CC functionality related to donor age. In detail, DEGs were found to be involved in important CC functions such as: aromatase activity (CYP19A), growth factor-binding proteins (ERBB3, IGFBP2/3, PDGFRA, ITGAV), mitochondrial functions (SOD1, ATP5MF-ATP, ATPase H+/K+, MT-COX1/2/3, ND4L, NDUFS4, COX17) and regulation of cell-cell/cell-matrix interactions mediated by: integrins (ITGA6/L/V, ITGB4/8), collagen (COL1A/3A/5A) and cadherins (CDH4/6/13/17/18/23, DSG2). These findings enhance understanding of molecular mechanisms underlying oocyte development from early life to fertile age and offer potential non-invasive biomarkers of oocyte quality of adult cyclic subjects.
ArticleNumber 117643
Author Dell’Aquila, Maria Elena
Bogliolo, Luisa
Pesole, Graziano
Ciani, Elena
Martino, Nicola Antonio
Mansi, Luigi
Ariu, Federica
Manzari, Caterina
Mastrorocco, Antonella
Temerario, Letizia
Picardi, Ernesto
Podda, Andrea
Parisi, Francesco
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  organization: Department of Veterinary Medicine, University of Sassari, Sassari, Italy
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  fullname: Dell’Aquila, Maria Elena
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Keywords Non-invasive biomarkers
Prepubertal lambs
Transcriptomic analysis
Cumulus cells
Oocyte quality
Adult sheep
Language English
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Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.
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Snippet Cumulus cells (CCs) are crucial during cumulus-oocyte complex (COC) growth, maturation and fertilization. Analysis of gene expression in CCs of in vitro...
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SubjectTerms Adult sheep
Cumulus cells
Non-invasive biomarkers
Oocyte quality
Prepubertal lambs
Transcriptomic analysis
Title Transcriptomic profile of cumulus cells isolated from cumulus-oocyte complexes of prepubertal and adult sheep
URI https://dx.doi.org/10.1016/j.theriogenology.2025.117643
https://www.ncbi.nlm.nih.gov/pubmed/40848424
https://www.proquest.com/docview/3246330128
Volume 249
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