Photoredox mediated annelation of iododifluoromethylated alcohols with 1,1-diarylethylenes

• Published in: Tetrahedron Vol. 74; no. 50; pp. 7136 - 7142
• Main Authors: Panferova, Liubov I., Chernov, Grigory N., Levin, Vitalij V., Kokorekin, Vladimir A., Dilman, Alexander D.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 13.12.2018; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Fluorinated alcohols; Organofluorine compounds; Photocatalysis; Physical Sciences; Radical reactions; Science & Technology; Tetrahydrofurans; Organofluorine compounds; Radical reactions; Photocatalysis; Fluorinated alcohols; Tetrahydrofurans; CATALYSIS; REAGENTS; GEMCITABINE; 3-COMPONENT OXYTRIFLUOROMETHYLATION; ALKENES; KETONES; DIFLUOROMETHYLATION; OLEFINATION; FLUOROALKYLATION REACTIONS; INHIBITOR

A method for the synthesis of 3,3-difluorotetrahydrofurans from iododifluoromethylated alcohols and 1,1-diarylethylenes is described. The reaction is performed under irradiation with 400 nm light emitting diodes in the presence of a cationic iridium(III) photocatalyst, [Ir(ppy)2(dtbbpy)]PF6, substoi...