Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 290; no. 4; pp. G665 - G673
• Main Authors: Fujiwara, Yasuhiro, Higuchi, Kazuhide, Takashima, Takashi, Hamaguchi, Masaki, Hayakawa, Tsuyoshi, Tominaga, Kazunari, Watanabe, Toshio, Oshitani, Nobuhide, Shimada, Yutaka, Arakawa, Tetsuo
• Format: Journal Article
• Language: English
• Published: United States 01.04.2006
• Subjects: Animals; Cell Line; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Epidermal Growth Factor - administration & dosage; Epidermal Growth Factor - metabolism; Epithelium - drug effects; Epithelium - metabolism; Epithelium - pathology; Esophagitis, Peptic - metabolism; Esophagitis, Peptic - pathology; Esophagus - drug effects; Esophagus - metabolism; Esophagus - pathology; Humans; Hydrogen-Ion Concentration; Male; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers - metabolism

Epidermal growth factor (EGF) is predominantly secreted by salivary glands and activates Na(+)/H(+) exchanger-1 (NHE-1), which regulates intracellular pH (pH(i)). We investigated the roles of EGF and NHE-1 in esophageal epithelial defense against acid using human esophageal epithelial cell lines and...