Development of near-infrared lysosomal pH-activatable fluorescent probe for real-time visualization of autophagy progression

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 464; p. 142554
• Main Authors: Feng, Bin, Ma, Yeshuo, Zheng, Fan, Huang, Xueyan, Feng, Xueping, Zhang, Kexiang, Liu, Li, Chen, Fei, Zeng, Wenbin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.05.2023
• Subjects: Acetaminophen-induced liver injury; Autophagy; Hemicyanine; Lysosome-targeting; Near-infrared; Acetaminophen-induced liver injury; Hemicyanine; Autophagy; Near-infrared; Lysosome-targeting

[Display omitted] •A novel lysosome-targeted probe (Lyso-QL) with pH-activatable NIR fluorescence was developed with high sensitivity and selectivity.•Lyso-QL presents a fast, reversible, and steady response to pH change and remarkerble Stokes shift.•Lyso-QL was successfully applied for motoring the...